Hilde Jørgensen, M. D. , Abby S. Hill, B. S. , Michael T. Beste, Ph. D

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Presentation transcript:

Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility Hilde Jørgensen, M.D., Abby S. Hill, B.S., Michael T. Beste, Ph.D., Manu P. Kumar, B.S., Evan Chiswick, Ph.D., Peter Fedorcsak, M.D., Ph.D., Keith B. Isaacson, M.D., Douglas A. Lauffenburger, Ph.D., Linda G. Griffith, Ph.D., Erik Qvigstad, M.D., Ph.D. Fertility and Sterility Volume 107, Issue 5, Pages 1191-1199.e2 (May 2017) DOI: 10.1016/j.fertnstert.2017.03.013 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) PLS-DA analysis of all 94 patients identifying a minimum set of predictive cytokines separating endometriosis from no endometriosis. Numbers on the x-axis represent covariation between each cytokine and endometriosis. (B) AUC according to number of class-separating cytokines removed from the original 47 cytokines measured. AUCs for random permuted combinations and observed combinations of cytokines are shown for validation. Fertility and Sterility 2017 107, 1191-1199.e2DOI: (10.1016/j.fertnstert.2017.03.013) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Supplemental Figure 1 ROC curves for the best models for discrimination of endometriosis versus no endometriosis. (A) The model includes all patients. SCGF-β, IL-13, and G-CSF were significantly predictive of endometriosis; AUC = 0.81. (B) Patients in follicular phase. SCGF-β was the only significantly predictive factor; AUC = 0.82. (C) Patients in luteal phase. HGF was the only significantly predictive factor in the multivariate model; AUC = 0.71. Fertility and Sterility 2017 107, 1191-1199.e2DOI: (10.1016/j.fertnstert.2017.03.013) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions