Fetal model of single ventricle physiology: Hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period V.Mohan.

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Presentation transcript:

Fetal model of single ventricle physiology: Hemodynamic effects of oxygen, nitric oxide, carbon dioxide, and hypoxia in the early postnatal period V.Mohan Reddy, MD, John R. Liddicoat, MD, Jeffrey R. Fineman, MD, Doff B. McElhinney, MS, Judith R. Klein, MD, Frank L. Hanley, MD The Journal of Thoracic and Cardiovascular Surgery Volume 112, Issue 2, Pages 437-449 (August 1996) DOI: 10.1016/S0022-5223(96)70272-6 Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 1 Completed surgical procedure for in utero creation of Damus-Kaye-Stansel anastomosis to achieve single ventricle physiology. A, Aortopulmonary shunt; Ao, ascending aorta; BT, brachiocephalic trunk; C, clip ligation of main pulmonary artery; D, Damus-Kaye-Stansel anastomosis; DA, ductus arteriosus; DAo, descending aorta; LPA, left pulmonary artery; PA, main pulmonary artery. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 2 Mean (± standard deviation) percent change in PAP after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 10) cardiopulmonary bypass. Percent and p values displayed directly above figure columns reflect the mean percent change and significance levels for the paired, two-tailed t test comparison between preadministration and postadministration PAP. Boxed p values indicate significance levels for paired two-tailed t test comparison between prebypass and postbypass mean percent change in PAP after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide (n = 10). The same format applies to Figs. 3 through 9. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 3 Mean (± standard deviation) percent change in SAP after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 9) cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 4 Mean (± standard deviation) percent change in indexed Qp after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 10) cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 5 Mean (± standard deviation) percent change in indexed Qs after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 10) cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 6 Mean (± standard deviation) percent change in Qp/Qs after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 10) cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 7 Mean (± standard deviation) percent change in PVR after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 10) cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 8 Mean (± standard deviation) percent change in SVR after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 10) cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions

Fig. 9 Mean (± standard deviation) percent change in PVR/SVR after administration of nitric oxide, 100% oxygen, hypoxia, and 5% carbon dioxide before (n = 11) and after (n = 10) cardiopulmonary bypass. The Journal of Thoracic and Cardiovascular Surgery 1996 112, 437-449DOI: (10.1016/S0022-5223(96)70272-6) Copyright © 1996 Mosby, Inc. Terms and Conditions