Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee H.R. Schumacher,

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Randomized double-blind crossover study of the efficacy of a tart cherry juice blend in treatment of osteoarthritis (OA) of the knee H.R. Schumacher, S. Pullman-Mooar, S.R. Gupta, J.E. Dinnella, R. Kim, M.P. McHugh Osteoarthritis and Cartilage Volume 21, Issue 8, Pages 1035-1041 (August 2013) DOI: 10.1016/j.joca.2013.05.009 Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Breakdown of randomization of treatments showing treatment order, number of patients completing each period of the study, withdrawals and AEs. One patient who sustained a back injury in the first treatment period (cherry juice) was not included in analysis of WOMAC scores because the back injury necessitated taking NSAIDs. Any improvement in WOMAC score was confounded by the potential benefit of the NSAID regardless of any effect of cherry juice. Osteoarthritis and Cartilage 2013 21, 1035-1041DOI: (10.1016/j.joca.2013.05.009) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Effect of decrease in hsCRP during cherry juice treatment on improvement in WOMAC scores. Black bars are patients that had >10% decrease in hsCRP. White bars are patients with ≤10% decrease in hsCRP. ∗Greater improvement in patients with decreased hsCRP vs patients with no change in hsCRP tested by independent t-test (WOMAC P = 0.01; Function P = 0.004; Pain P = 0.23; Stiffness P = 0.82). Mean ± standard error (SE) for % improvement in WOMAC scores displayed. Osteoarthritis and Cartilage 2013 21, 1035-1041DOI: (10.1016/j.joca.2013.05.009) Copyright © 2013 Osteoarthritis Research Society International Terms and Conditions