Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age Rosalía Ayuso, MD, PhD,

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Greater epitope recognition of shrimp allergens by children than by adults suggests that shrimp sensitization decreases with age Rosalía Ayuso, MD, PhD, Silvia Sánchez-Garcia, MD, Jing Lin, PhD, Zhiyan Fu, PhD, María Dolores Ibáñez, MD, PhD, Teresa Carrillo, MD, PhD, Carlos Blanco, MD, PhD, Marina Goldis, MD, Ludmila Bardina, MS, Joaquín Sastre, MD, PhD, Hugh A. Sampson, MD Journal of Allergy and Clinical Immunology Volume 125, Issue 6, Pages 1286-1293.e3 (June 2010) DOI: 10.1016/j.jaci.2010.03.010 Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 1 IgE epitope identification in tropomyosin, MLC, SCP, and AK. Peptides are represented on the x-axis. The fluorescent intensity of each peptide (weighted average z scores) is represented on the left y-axis. Boxes represent the median and 25% to 75% quartiles, and whiskers represent the 10% to 90% distribution. Right y-axis, Frequency of recognition of each peptide. A, Tropomyosin. B, MLC. C, SCP. D, AK. Journal of Allergy and Clinical Immunology 2010 125, 1286-1293.e3DOI: (10.1016/j.jaci.2010.03.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 2 Comparison of shrimp epitope recognition by children and adults. All peptides from the 4 allergenic proteins are represented in rows. The recognition of peptides by each of the 53 subjects (1-19, adults; 20-53, children) are shown in the columns. The intensity of IgE binding is represented by weighted average z scores in a grading scale ranging from less than 3 (white) to 10 or greater (red). Journal of Allergy and Clinical Immunology 2010 125, 1286-1293.e3DOI: (10.1016/j.jaci.2010.03.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions

Fig 3 Inhibition of IgE binding to tropomyosin peptides. Tropomyosin peptides (1-91) are shown in rows. Left column, Peptides recognized by a pool of 5 subjects. Right column, Reactivity to the same peptides after preinhibition with tropomyosin peptide 15 (TP-15). The intensity of recognition is graded from white (z score <3) to red (z score ≥10). In most peptides showing inhibition of IgE binding, the sequence LEX1X2L or LEX1X2N is seen. Journal of Allergy and Clinical Immunology 2010 125, 1286-1293.e3DOI: (10.1016/j.jaci.2010.03.010) Copyright © 2010 American Academy of Allergy, Asthma & Immunology Terms and Conditions