Total respiratory support from swine lungs in primate recipients

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Total respiratory support from swine lungs in primate recipients C.William Daggett, MDa, Mark Yeatman, FRCSa, Andrew J. Lodge, MDa, Edward P. Chen, MDa, Shu S. Linn, MDa, Carmelo Gullotto, BBAa, Michael M. Frank, MDb, Jeffrey L. Platt, MDa,b, R.Duane Davis, MDa, Ross M. Ungerleider, MD The Journal of Thoracic and Cardiovascular Surgery Volume 115, Issue 1, Pages 19-27 (January 1998) DOI: 10.1016/S0022-5223(98)70438-6 Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 1 Diagram of extracorporeal perfusion circuit. Blood is removed from the baboon inferior vena cava and delivered to the swine main pulmonary artery with a roller pump. Blood is drained into a reservoir and returned to the baboon with a second roller pump. The lungs are ventilated with an inspired oxygen fraction of 0.6, and the peak inspiratory pressure is maintained between 25 to 30 cm H2O during the procedure. IVC, Inferior vena cava; RA, right atrium. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 19-27DOI: (10.1016/S0022-5223(98)70438-6) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 2 PVR of immunodepleted baboons before transplantation and after transplantation with the right pulmonary artery occluded at 1 hour. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 19-27DOI: (10.1016/S0022-5223(98)70438-6) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 3 Arterial oxygen tension. Oxygenation of immunodepleted baboons before transplantation and after transplantation with the right pulmonary artery occluded at 1 hour. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 19-27DOI: (10.1016/S0022-5223(98)70438-6) Copyright © 1998 Mosby, Inc. Terms and Conditions

Figure 4 Arterial carbon dioxide tension. Ventilation of immunodepleted baboons before transplantation and after transplantation with the right pulmonary artery occluded at 1 hour. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 19-27DOI: (10.1016/S0022-5223(98)70438-6) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 5 Cardiac output of immunodepleted baboons before transplantation and after transplantation with the pulmonary artery occluded at 1 hour. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 19-27DOI: (10.1016/S0022-5223(98)70438-6) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 6 Systolic blood pressure of immunodepleted baboons before transplantation and after transplantation with the right pulmonary artery occluded at 1 hour. The Journal of Thoracic and Cardiovascular Surgery 1998 115, 19-27DOI: (10.1016/S0022-5223(98)70438-6) Copyright © 1998 Mosby, Inc. Terms and Conditions

Fig. 7 Light micrographs (hematoxylin and eosin stain) of porcine pulmonary xenografts at 1 hour after transplantation in control baboons (A) and immunodepleted baboons (B) and at 3 hours after transplantation in control (C) and immunodepleted baboons (D). Eleven-hour micrograph of a pulmonary xenograft transplanted into an immunodepleted baboon (E). The Journal of Thoracic and Cardiovascular Surgery 1998 115, 19-27DOI: (10.1016/S0022-5223(98)70438-6) Copyright © 1998 Mosby, Inc. Terms and Conditions