Nonporous silicone polymer coating of expanded polytetrafluoroethylene grafts reduces graft neointimal hyperplasia in dog and baboon models Alan B. Lumsden,

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Presentation transcript:

Nonporous silicone polymer coating of expanded polytetrafluoroethylene grafts reduces graft neointimal hyperplasia in dog and baboon models Alan B. Lumsden, MB, ChB, Changyi Chen, MD, Kelly A. Coyle, MD, John C. Ofenloch, MD, Jenn-Hann Wang, PhD, Hirutsugu K. Yasuda, PhD, Stephen R. Hanson, PhD Journal of Vascular Surgery Volume 24, Issue 5, Pages 825-833 (November 1996) DOI: 10.1016/S0741-5214(96)70019-8 Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Scanning electron microscope image of graft luminal surfaces. A, Untreated ePTFE graft (30 μm internodal distance) exhibits usual nodes and fibrils that characterize conventional ePTFE graft surface (original magnification, ×500). B, Scanning electron microscope image of treated ePTFE grafts shows that fibrillar-nodular structures were totally obscured by polymer coating (about 50 μm thick). Journal of Vascular Surgery 1996 24, 825-833DOI: (10.1016/S0741-5214(96)70019-8) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Scanning electron microscope image of graft luminal surfaces. A, Untreated ePTFE graft (30 μm internodal distance) exhibits usual nodes and fibrils that characterize conventional ePTFE graft surface (original magnification, ×500). B, Scanning electron microscope image of treated ePTFE grafts shows that fibrillar-nodular structures were totally obscured by polymer coating (about 50 μm thick). Journal of Vascular Surgery 1996 24, 825-833DOI: (10.1016/S0741-5214(96)70019-8) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic sections of neointimal tissue from femoral AV grafts in canine model. A, Neointimal tissue was present in untreated graft at venous anastomosis. B, A small portion of neointimal tissue was present in silicone-treated graft at venous anastomosis. Verhoeff-Masson's stain (original magnification, ×100). Journal of Vascular Surgery 1996 24, 825-833DOI: (10.1016/S0741-5214(96)70019-8) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 Histologic sections of neointimal tissue from femoral AV grafts in canine model. A, Neointimal tissue was present in untreated graft at venous anastomosis. B, A small portion of neointimal tissue was present in silicone-treated graft at venous anastomosis. Verhoeff-Masson's stain (original magnification, ×100). Journal of Vascular Surgery 1996 24, 825-833DOI: (10.1016/S0741-5214(96)70019-8) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Histologic sections of neointimal anastomotic tissue from aortoiliac ePTFE grafts placed in baboons. A, Significant neointimal tissue (N) was present in uncoated anastomosis, overlying ePTFE graft (G), and some neointima is present overlying media (M) of adjacent vessel. B, Minimal neointimal hyperplasia (N) is seen overlying polymer-coated graft surface (G), although a large neointima is seen luminal to vessel media (M) (original magnification, ×30). Journal of Vascular Surgery 1996 24, 825-833DOI: (10.1016/S0741-5214(96)70019-8) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 3 Histologic sections of neointimal anastomotic tissue from aortoiliac ePTFE grafts placed in baboons. A, Significant neointimal tissue (N) was present in uncoated anastomosis, overlying ePTFE graft (G), and some neointima is present overlying media (M) of adjacent vessel. B, Minimal neointimal hyperplasia (N) is seen overlying polymer-coated graft surface (G), although a large neointima is seen luminal to vessel media (M) (original magnification, ×30). Journal of Vascular Surgery 1996 24, 825-833DOI: (10.1016/S0741-5214(96)70019-8) Copyright © 1996 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions