L. J. Downing, MD, T. W. Wakefield, MD, R. M. Strieter, MD, M. R

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Presentation transcript:

Anti-P-selectin antibody decreases inflammation and thrombus formation in venous thrombosis L.J. Downing, MD, T.W. Wakefield, MD, R.M. Strieter, MD, M.R. Prince, MD, PhD, F.J. Londy, RT, J.B. Fowlkes, PhD, M.S. Hulin, DVM, A.M. Kadell, BS, C.A. Wilke, BA, S.L. Brown, BS, S.K. Wrobleski, BS, M.D. Burdick, BS, D.C. Anderson, MD, L.J. Greenfield, MD Journal of Vascular Surgery Volume 25, Issue 5, Pages 816-828 (May 1997) DOI: 10.1016/S0741-5214(97)70211-8 Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Representative vein wall histologic pattern of control baboons, GA6-treated baboons, and CY1748-treated baboons at day 2. In the control baboon (A, original magnification, 200×), neutrophils (closed arrows) were found localizing at the vein wall/thrombus interface (open arrows) and extending into the vein wall from both the luminal and adventitial sides of the vein wall. In the majority of GA6-treated baboons (B, original magnification, 200×), no thrombus was identified in the lumen and the vein wall was devoid of a dense inflammatory cell influx. In the CY1748-treated baboon (C, original magnification, 200×), similar findings were noted as were found in the GA6-treated group. However, in one of the CY1748-treated baboons (day 6), the proximal IVC (D, original magnification, 400×) demonstrated numerous neutrophils lined up at the vein wall endothelium interface (open arrows), which did not fully traverse into the vein wall. n, Neutrophils; w, wall; L, lumen; t, thrombus. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Representative vein wall histologic pattern of control baboons, GA6-treated baboons, and CY1748-treated baboons at day 2. In the control baboon (A, original magnification, 200×), neutrophils (closed arrows) were found localizing at the vein wall/thrombus interface (open arrows) and extending into the vein wall from both the luminal and adventitial sides of the vein wall. In the majority of GA6-treated baboons (B, original magnification, 200×), no thrombus was identified in the lumen and the vein wall was devoid of a dense inflammatory cell influx. In the CY1748-treated baboon (C, original magnification, 200×), similar findings were noted as were found in the GA6-treated group. However, in one of the CY1748-treated baboons (day 6), the proximal IVC (D, original magnification, 400×) demonstrated numerous neutrophils lined up at the vein wall endothelium interface (open arrows), which did not fully traverse into the vein wall. n, Neutrophils; w, wall; L, lumen; t, thrombus. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Representative vein wall histologic pattern of control baboons, GA6-treated baboons, and CY1748-treated baboons at day 2. In the control baboon (A, original magnification, 200×), neutrophils (closed arrows) were found localizing at the vein wall/thrombus interface (open arrows) and extending into the vein wall from both the luminal and adventitial sides of the vein wall. In the majority of GA6-treated baboons (B, original magnification, 200×), no thrombus was identified in the lumen and the vein wall was devoid of a dense inflammatory cell influx. In the CY1748-treated baboon (C, original magnification, 200×), similar findings were noted as were found in the GA6-treated group. However, in one of the CY1748-treated baboons (day 6), the proximal IVC (D, original magnification, 400×) demonstrated numerous neutrophils lined up at the vein wall endothelium interface (open arrows), which did not fully traverse into the vein wall. n, Neutrophils; w, wall; L, lumen; t, thrombus. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 1 Representative vein wall histologic pattern of control baboons, GA6-treated baboons, and CY1748-treated baboons at day 2. In the control baboon (A, original magnification, 200×), neutrophils (closed arrows) were found localizing at the vein wall/thrombus interface (open arrows) and extending into the vein wall from both the luminal and adventitial sides of the vein wall. In the majority of GA6-treated baboons (B, original magnification, 200×), no thrombus was identified in the lumen and the vein wall was devoid of a dense inflammatory cell influx. In the CY1748-treated baboon (C, original magnification, 200×), similar findings were noted as were found in the GA6-treated group. However, in one of the CY1748-treated baboons (day 6), the proximal IVC (D, original magnification, 400×) demonstrated numerous neutrophils lined up at the vein wall endothelium interface (open arrows), which did not fully traverse into the vein wall. n, Neutrophils; w, wall; L, lumen; t, thrombus. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MRV with Gd enhancement of the IVC and RI vein of a control baboon, GA6-treated baboon, and CY1748-treated baboon, all at day 2 after thrombus induction. In the control baboon, IVC and RI segments (A and B), Gd enhancement (closed arrows) is noted involving the vein wall segments and perivenous adventitial tissue, associated with intraluminal clot. In the GA6-treated baboon (C and D) and the CY1748-treated baboon (E and F), little Gd enhancement was noted as compared with the control group. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MRV with Gd enhancement of the IVC and RI vein of a control baboon, GA6-treated baboon, and CY1748-treated baboon, all at day 2 after thrombus induction. In the control baboon, IVC and RI segments (A and B), Gd enhancement (closed arrows) is noted involving the vein wall segments and perivenous adventitial tissue, associated with intraluminal clot. In the GA6-treated baboon (C and D) and the CY1748-treated baboon (E and F), little Gd enhancement was noted as compared with the control group. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MRV with Gd enhancement of the IVC and RI vein of a control baboon, GA6-treated baboon, and CY1748-treated baboon, all at day 2 after thrombus induction. In the control baboon, IVC and RI segments (A and B), Gd enhancement (closed arrows) is noted involving the vein wall segments and perivenous adventitial tissue, associated with intraluminal clot. In the GA6-treated baboon (C and D) and the CY1748-treated baboon (E and F), little Gd enhancement was noted as compared with the control group. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MRV with Gd enhancement of the IVC and RI vein of a control baboon, GA6-treated baboon, and CY1748-treated baboon, all at day 2 after thrombus induction. In the control baboon, IVC and RI segments (A and B), Gd enhancement (closed arrows) is noted involving the vein wall segments and perivenous adventitial tissue, associated with intraluminal clot. In the GA6-treated baboon (C and D) and the CY1748-treated baboon (E and F), little Gd enhancement was noted as compared with the control group. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MRV with Gd enhancement of the IVC and RI vein of a control baboon, GA6-treated baboon, and CY1748-treated baboon, all at day 2 after thrombus induction. In the control baboon, IVC and RI segments (A and B), Gd enhancement (closed arrows) is noted involving the vein wall segments and perivenous adventitial tissue, associated with intraluminal clot. In the GA6-treated baboon (C and D) and the CY1748-treated baboon (E and F), little Gd enhancement was noted as compared with the control group. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions

Fig. 2 MRV with Gd enhancement of the IVC and RI vein of a control baboon, GA6-treated baboon, and CY1748-treated baboon, all at day 2 after thrombus induction. In the control baboon, IVC and RI segments (A and B), Gd enhancement (closed arrows) is noted involving the vein wall segments and perivenous adventitial tissue, associated with intraluminal clot. In the GA6-treated baboon (C and D) and the CY1748-treated baboon (E and F), little Gd enhancement was noted as compared with the control group. Journal of Vascular Surgery 1997 25, 816-828DOI: (10.1016/S0741-5214(97)70211-8) Copyright © 1997 Society for Vascular Surgery and International Society for Cardiovascular Surgery, North American Chapter Terms and Conditions