Indocyanine green angiography: A new method to quantify collateral flow in mice Jan C. Wuestenfeld, MD, Joerg Herold, MD, Ulrike Niese, Utz Kappert, MD,

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Presentation transcript:

Indocyanine green angiography: A new method to quantify collateral flow in mice Jan C. Wuestenfeld, MD, Joerg Herold, MD, Ulrike Niese, Utz Kappert, MD, Alexander Schmeisser, MD, Ruth H. Strasser, MD, Ruediger C. Braun-Dullaeus, MD Journal of Vascular Surgery Volume 48, Issue 5, Pages 1315-1321 (November 2008) DOI: 10.1016/j.jvs.2008.06.049 Copyright © 2008 Terms and Conditions

Fig 1 A, Hind limb perfusion in two regions of interest (red and green squares) of a (left) ligated and (right) unligated leg. A standard sponge (red arrow) and a reference area (white arrow) were simultaneously imaged to eliminate background signals. B, False-color images show the hind limb perfusion. High perfusion of the unligated leg and tail, and hypoperfusion of the ligated leg, were observed directly after occlusion. C, The influx velocity of indocyanine green, determined as the increase of fluorescence intensity in the regions of interest, is represented by the slope of the red (ligated area) and green (unligated area) curves. The standard sponge (yellow line) was used to eliminate background signals. The black bar indicates the time point of measurement for maximal fluorescence intensity after 20 seconds when maximal perfusion was observed in the unligated leg. D, Laser Doppler perfusion imaging of a mouse foot span demonstrates superficial skin perfusion 1 week after the ligation. Journal of Vascular Surgery 2008 48, 1315-1321DOI: (10.1016/j.jvs.2008.06.049) Copyright © 2008 Terms and Conditions

Fig 2 Top, Time course of blood flow given as the perfusion index (slope of pixel intensity, ligated/unligated; blue bars) and maximal pixel intensity (ligated/unligated; red bars; n = 7). The green bars represent the results of laser Doppler perfusion imaging measurement. Error bars represent the standard error of the mean. A to E, Representative false-color images show the regions of interest in a ligated (red square) and unligated (green) hind limb. Mean signal intensity of the reference regions is green, lower fluorescence intensity is blue–green, and higher fluorescence intensities are gradually represented by yellow, orange, and red. Journal of Vascular Surgery 2008 48, 1315-1321DOI: (10.1016/j.jvs.2008.06.049) Copyright © 2008 Terms and Conditions

Fig 3 Direct visualization of collateral arteries (white arrows) in representative (left) ligated and (right) unligated hind limbs during indocyanine green perfusion. Journal of Vascular Surgery 2008 48, 1315-1321DOI: (10.1016/j.jvs.2008.06.049) Copyright © 2008 Terms and Conditions

Fig 4 Postmortem angiography of an (A) unligated and (B) ligated mouse hind limb. A few visible collaterals span the occlusion side (red arrows). Journal of Vascular Surgery 2008 48, 1315-1321DOI: (10.1016/j.jvs.2008.06.049) Copyright © 2008 Terms and Conditions

Fig 5 Collateral arteries increase after ligation. The ligated/unligated ratio of collateral arteries was calculated for each animal (n = 7 for each group). Error bars designate the standard error of the mean. Journal of Vascular Surgery 2008 48, 1315-1321DOI: (10.1016/j.jvs.2008.06.049) Copyright © 2008 Terms and Conditions