Effects of Extended Pleurectomy and Decortication on Quality of Life and Pulmonary Function in Patients With Malignant Pleural Mesothelioma David Burkholder,

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Effects of Extended Pleurectomy and Decortication on Quality of Life and Pulmonary Function in Patients With Malignant Pleural Mesothelioma David Burkholder, BS, Duraid Hadi, MD, Rangesh Kunnavakkam, PhD, Hedy Kindler, MD, Kristy Todd, PA-C, Amy Durkin Celauro, PA- C, Wickii T. Vigneswaran, MD The Annals of Thoracic Surgery Volume 99, Issue 5, Pages 1775-1780 (May 2015) DOI: 10.1016/j.athoracsur.2015.01.058 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 European Organization for Research and Treatment of Cancer Core Quality of Life Questionaire-C30 mean scores of (A) functional scales and (B) symptom scales in performance status (PS) 0 (striped bars) and PS 1 (solid bars) patients at baseline. ∗Indicates two-sample Student’s t test shows a significant difference (p < 0.05) between baseline means of PS 0 and PS 1 groups. (QoL = quality of life.) The Annals of Thoracic Surgery 2015 99, 1775-1780DOI: (10.1016/j.athoracsur.2015.01.058) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 European Organization for Research and Treatment of Cancer Core Quality of Life Questionaire-C30 domain changes from baseline at 4 to 5 (solid bars) and 7 to 8 months (striped bars) for performance status (PS) 0 and PS 1 groups. (A) PS 1 and 2 quality of life (QoL) changes; (B) PS 0 quality of life changes. ∗Indicates significant change (p < 0.05), probability value acquired from Student’s t test: paired two sample for means. The Annals of Thoracic Surgery 2015 99, 1775-1780DOI: (10.1016/j.athoracsur.2015.01.058) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Mean change in pulmonary function testing (% predicted). ∗p < 0.05. (Dlco = diffusing capacity of the lung for carbon monoxide; FEV1 = forced expiratory volume in 1 second; FRC = functional residual capacity; FVC = forced vital capacity; PS = performance status; RV = residual volume; TLC = total lung capacity.) The Annals of Thoracic Surgery 2015 99, 1775-1780DOI: (10.1016/j.athoracsur.2015.01.058) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions