Volume 69, Issue 3, Pages 718-735 (September 2018) Burden of liver disease in Europe: Epidemiology and analysis of risk factors to identify prevention policies  Laura Pimpin, Helena Cortez-Pinto, Francesco Negro, Emily Corbould, Jeffrey V. Lazarus, Laura Webber, Nick Sheron  Journal of Hepatology  Volume 69, Issue 3, Pages 718-735 (September 2018) DOI: 10.1016/j.jhep.2018.05.011 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Journal of Hepatology 2018 69, 718-735DOI: (10. 1016/j. jhep. 2018. 05 Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 1 Age-standardised prevalence of cirrhosis and other liver diseases by aetiology in 2016 – modelled data.1 Median prevalence for alcohol use: 312 per 100,000; median prevalence for hepatitis B 130 per 100,000; median prevalence for hepatitis C: 212 per 100,000, median prevalence for other causes 116 per 100,000. Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Age-standardised mortality for all liver diseases – in most recent year.5 Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 3 Total mortality from cirrhosis (top) and alcohol consumption (bottom) over time, for ages >15 years for countries in different trend groups. (A) Decreasing, (B) increasing, (C) stable-high, (D) stable-low.6 Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 4 Death rates, cirrhosis of the liver and alcohol consumption reproduced with permission from Terris (1967).22 Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 5 Alcohol consumption and age-standardised mortality from cirrhosis and chronic liver diseases (blue filled) on the left and alcoholic liver disease mortality (blue dashed) (left) and total consumption of alcohol by type of alcohol ages >15 yr (right) in four countries. (A) France, (B) UK, (C) Czech Republic.6 Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 6 Trends in liver mortality in Finland following entry of Estonia into the EU, a dramatic increase in liver mortality was stabilised by a strong policy response. Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 7 Time trends in age-standardised mortality from NAFLD/NASH – both genders by region. (A) Northern, (B) Eastern, (C) Southern, (D) Western Europe.5 Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 8 Prevalence of obesity (BMI >30 kg/m2) in females and males in the most recent year available. Estimates come from measured BMI, all other data points used self-reported. Note: Uzbekistan estimates come from surveys in separate years and so are presented separately. Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 9 Age-standardised national prevalence of type 2 diabetes in adults (both genders) aged 20–79 years over time by region. (A) Northern, (B) Eastern, (C) Southern, (D) Western Europe. Estimation methodology was revised in 2011.13 Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions

Fig. 10 Map of the age-adjusted prevalence of type 2 diabetes in adults, both genders (2015).13 Journal of Hepatology 2018 69, 718-735DOI: (10.1016/j.jhep.2018.05.011) Copyright © 2018 European Association for the Study of the Liver Terms and Conditions