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Presentation transcript:

Volume 14, Issue 11, Pages 1086-1094 (October 2013) The UK Standardisation of Breast Radiotherapy (START) trials of radiotherapy hypofractionation for treatment of early breast cancer: 10-year follow-up results of two randomised controlled trials Joanne S Haviland, MSc, J Roger Owen, FRCR, Prof John A Dewar, FRCR, Rajiv K Agrawal, FRCR, Jane Barrett, FRCR, Prof Peter J Barrett-Lee, MD, H Jane Dobbs, FRCR, Penelope Hopwood, MD, Pat A Lawton, PhD, Brian J Magee, FRCR, Judith Mills, MPhil, Sandra Simmons, Mark A Sydenham, BSc, Karen Venables, PhD, Prof Judith M Bliss, MSc, Prof John R Yarnold, FRCR The Lancet Oncology Volume 14, Issue 11, Pages 1086-1094 (October 2013) DOI: 10.1016/S1470-2045(13)70386-3 Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 1 Cumulative risk of local-regional tumour relapse In START-A (A) and START-B (B). The Lancet Oncology 2013 14, 1086-1094DOI: (10.1016/S1470-2045(13)70386-3) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 2 Kaplan-Meier analysis of disease-free survival In START-A (A) and START-B (B). The Lancet Oncology 2013 14, 1086-1094DOI: (10.1016/S1470-2045(13)70386-3) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 3 Late normal tissue effects In START-A (A) and START-B (B). Assessed as moderate or marked by physicians. The Lancet Oncology 2013 14, 1086-1094DOI: (10.1016/S1470-2045(13)70386-3) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 4 Meta-analysis of local-regional relapse comparing hypofractionated regimens versus 50 Gy in 25 fractions Includes 5861 patients from the START pilot trial, START-A, and START-B. The Lancet Oncology 2013 14, 1086-1094DOI: (10.1016/S1470-2045(13)70386-3) Copyright © 2013 Elsevier Ltd Terms and Conditions

Figure 5 Meta-analysis of any moderate or marked physician-assessed normal tissue effects in the breast comparing hypofractionated regimens versus 50 Gy in 25 fractions Includes 4672 patients from START pilot trial, START-A, and START-B. *Assessed from baseline photographs. The Lancet Oncology 2013 14, 1086-1094DOI: (10.1016/S1470-2045(13)70386-3) Copyright © 2013 Elsevier Ltd Terms and Conditions