Performance of serum marker panels for liver fibrosis in chronic hepatitis C  Julie Parkes, Indra Neil Guha, Paul Roderick, William Rosenberg  Journal of Hepatology  Volume 44, Issue 3, Pages 462-474 (March 2006) DOI: 10.1016/j.jhep.2005.10.019 Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

Fig. 1 (a–d) Summative receiver operator characteristic curves of panels of serum markers diagnostic of liver fibrosis at different thresholds (95% confidence intervals). (a) Mid-range thresholds: summative statistics. Diagnostic odds ratio: 6.52 (1.69–25.23); Sensitivity: 59.8%; Specificity: 87.7%. (b) Lowest reported thresholds: summative statistics. Diagnostic odds ratio: 6.39 (1.89–21.65); Sensitivity: 94.8%; Specificity: 35.8%. (c) Highest reported thresholds: Summative statistics. Diagnostic odds ratio: 8.14 (3.61–18.38); Specificity: 95%; Sensitivity: 40.1%. (d) All thresholds for all panels of tests: Summative statistics. Diagnostic odds ratio: 9.96 (8.15–12). Specificity: 71%; Sensitivity: 80%. Test for heterogeneity P=<0.0001. Journal of Hepatology 2006 44, 462-474DOI: (10.1016/j.jhep.2005.10.019) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions

Fig. 2 Correct: biopsies avoided correctly (true positive true negative). Incorrect: biopsies avoided incorrectly (false negative). Inaccurate: cannot reliably attribute result for tests as tests perform with lower sensitivities/specificities at thresholds, where PPV<90%, NPV<95%. [This figure appears in colour on the web.] Journal of Hepatology 2006 44, 462-474DOI: (10.1016/j.jhep.2005.10.019) Copyright © 2005 European Association for the Study of the Liver Terms and Conditions