Louise A. Kelly-Hope, Harriet J. Blundell, Cara L. Macfarlane, David H

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Presentation transcript:

Innovative Surveillance Strategies to Support the Elimination of Filariasis in Africa Louise A. Kelly-Hope, Harriet J. Blundell, Cara L. Macfarlane, David H. Molyneux Trends in Parasitology Volume 34, Issue 8, Pages 694-711 (August 2018) DOI: 10.1016/j.pt.2018.05.004 Copyright © 2018 The Authors Terms and Conditions

Figure 1 Key Components of Public Health Surveillance. Trends in Parasitology 2018 34, 694-711DOI: (10.1016/j.pt.2018.05.004) Copyright © 2018 The Authors Terms and Conditions

Figure 2 LF and Onchocerciasis Control and Elimination Frameworks. Also see [14]. Trends in Parasitology 2018 34, 694-711DOI: (10.1016/j.pt.2018.05.004) Copyright © 2018 The Authors Terms and Conditions

Figure 3 Tabulated Summary of Lymphatic Filariasis, Onchocerciasis, and Loiasis Diagnostics. aDiagnostic tests for bancroftian lymphatic filariasis (caused by infection with W. bancrofti) only are discussed here. bThere are currently no commercial tests available for programmatic use. Antigen-detection tests so far have not had the necessary sensitivity or specificity, or been practical for use in the field. cThis test was developed and evaluated, but it was not commercialised and is not in use. dThe Loa Antibody Rapid Test is for Research Use Only (RUO), and is indicated mainly for epidemiological and not diagnostic purposes. ePoint-of-care tests (POCTs) that can detect biomarkers of active onchocerciasis infection are not yet available, but several promising biomarkers are being evaluated. fThere are no POCTs for detecting biomarkers of current infection with loiasis; however, there are potential biomarkers under review. Abbreviations: ICT, immunochromatographic card test; RDT, rapid diagnostic test; ELISA, enzyme-linked immunosorbent assay; PCR, polymerase chain reaction. Trends in Parasitology 2018 34, 694-711DOI: (10.1016/j.pt.2018.05.004) Copyright © 2018 The Authors Terms and Conditions

Figure 4 Sub-Saharan African Maps of Lymphatic Filariasis, Onchocerciasis, and Loiasis Distribution. LF, lymphatic filariasis; REMO, Rapid Epidemiological Mapping of Onchocerciasis; RAPLOA, Rapid Assessment Procedure for Loiasis. Trends in Parasitology 2018 34, 694-711DOI: (10.1016/j.pt.2018.05.004) Copyright © 2018 The Authors Terms and Conditions