Supplementary Figure S1

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Supplementary Figure S1 NPM-ALK GAPDH DEL SU-DHL-1 SUP-M2 ATO (μM) 0 0.5 1 2 0 0.5 1 2 0 0.5 1 2 Supplementary Figure S1

Supplementary Figure S2 NPM-ALK β-actin MG-132 ATO (μM) - 2 + 4 8 SU-DHL-1 - 2 + 4 SUP-M2 MG-132 ATO(μM) NPM-ALK β-actin

Supplementary Figure S3 MG-132 ATO (μM) - 2 4 + IP: ALK IB: ALK IB: Ubiquitin NPM-ALK + (Ub)n 100kD NPM-ALK 130kD

Supplementary Figure S4 Ctrl ATO NAC NAC and ATO events Dihydroethidium DEL SU-DHL-1 SUP-M2

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Supplementary Figure S6