Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A2A receptor activation Turner C. Lisle, MD, Leo M. Gazoni, MD, Lucas.

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Presentation transcript:

Inflammatory lung injury after cardiopulmonary bypass is attenuated by adenosine A2A receptor activation Turner C. Lisle, MD, Leo M. Gazoni, MD, Lucas G. Fernandez, MD, Ashish K. Sharma, MBBS, Andrew M. Bellizzi, MD, Grant D. Schifflett, BA, Victor E. Laubach, PhD, Irving L. Kron, MD The Journal of Thoracic and Cardiovascular Surgery Volume 136, Issue 5, Pages 1280-1288 (November 2008) DOI: 10.1016/j.jtcvs.2008.07.010 Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 Schematic diagram of the rat CPB circuit and surgical cannulations. Ventilator not shown. MAP, Mean arterial pressure. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1280-1288DOI: (10.1016/j.jtcvs.2008.07.010) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 BAL MPO. SHAM (n = 5), CONTROL (n = 5), ATL (n = 5). ∗P < .05 versus sham and ATL. MPO, Myeloperoxidase. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1280-1288DOI: (10.1016/j.jtcvs.2008.07.010) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 Wet/dry analysis. SHAM (n = 5), CONTROL (n = 5), ATL (n = 5). ∗P < .001 versus SHAM and ATL. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1280-1288DOI: (10.1016/j.jtcvs.2008.07.010) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions

Figure 4 Representative hematoxylin-eosin sections of lung tissue. A, SHAM group: Normal-appearing pneumocytes apposed to capillaries are observed, without evidence of inflammatory infiltrate, alveolar macrophages, or edema. B, CONTROL group: Alveolar septa are substantially widened, and there are multiple alveolar macrophages and significant edema. C, ATL group: Alveolar septa are minimally widened by interstitial infiltrate, very few alveolar macrophages are observed, and there is sparse edema. The Journal of Thoracic and Cardiovascular Surgery 2008 136, 1280-1288DOI: (10.1016/j.jtcvs.2008.07.010) Copyright © 2008 The American Association for Thoracic Surgery Terms and Conditions