Targeting Lewis Y (Ley) in Small Cell Lung Cancer with a Humanized Monoclonal Antibody, hu3S193: A Pilot Trial Testing Two Dose Levels Lee M. Krug, MD,

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Presentation transcript:

Targeting Lewis Y (Ley) in Small Cell Lung Cancer with a Humanized Monoclonal Antibody, hu3S193: A Pilot Trial Testing Two Dose Levels Lee M. Krug, MD, Daniel T. Milton, MD, Achim A. Jungbluth, MD, Lin-Chi Chen, MD, Emilio Quaia, MD, Neeta Pandit-Taskar, MD, Andrew Nagel, Jessica Jones, Mark G. Kris, MD, Ronald Finn, PhD, Peter Smith-Jones, PhD, Andrew M. Scott, Lloyd Old, MD, Chaitanya Divgi, MD Journal of Thoracic Oncology Volume 2, Issue 10, Pages 947-952 (October 2007) DOI: 10.1097/JTO.0b013e3181560dcc Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 1 Small-cell lung cancer tumors showing 1+ (A) or 4+ (B) immunohistochemical staining with mu3S193. Journal of Thoracic Oncology 2007 2, 947-952DOI: (10.1097/JTO.0b013e3181560dcc) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 2 Patient 1 with left rib lesion and right pleural disease. Computed tomography (CT) scan (A) showing left rib lesion, and fluorodeoxyglucose positron emission tomography/CT fused image (B) showing intense uptake in left rib lesion. Indium-111 humanized 3S193 single-photon emission computed tomography (SPECT) axial image (C) and SPECT/CT fused image (D) shows uptake of antibody in left rib lesion. Journal of Thoracic Oncology 2007 2, 947-952DOI: (10.1097/JTO.0b013e3181560dcc) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions

FIGURE 3 Patient 2 with a liver metastasis. Computed tomography (CT) scan (A) showing liver lesion and positron emission tomography/CT fused image (B) showing uptake of fluorodeoxyglucose in the lesion. Indium-111 humanized 3S193 single-photon emission computed tomography (SPECT) axial image (C) and fused SPECT/CT image (D) shows antibody concentration in the liver lesion. Journal of Thoracic Oncology 2007 2, 947-952DOI: (10.1097/JTO.0b013e3181560dcc) Copyright © 2007 International Association for the Study of Lung Cancer Terms and Conditions