Hilly or mountainous surface: a new CT feature to predict the behavior of pure ground glass nodules? Andrea Borghesi, Silvia Michelini, Francesco Bertagna,

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Hilly or mountainous surface: a new CT feature to predict the behavior of pure ground glass nodules? Andrea Borghesi, Silvia Michelini, Francesco Bertagna, Alessandra Scrimieri, Stefania Pezzotti, Roberto Maroldi European Journal of Radiology Open Volume 5, Pages 177-182 (January 2018) DOI: 10.1016/j.ejro.2018.09.004 Copyright © 2018 The Authors Terms and Conditions

European Journal of Radiology Open 2018 5, 177-182DOI: (10. 1016/j European Journal of Radiology Open 2018 5, 177-182DOI: (10.1016/j.ejro.2018.09.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 1 Serial MDCT scans of the stable pGGN. (A) The baseline MDCT shows a pGGN (mean diameter, 10 mm) in the posterior segment of the right upper lobe. The follow-up CT scans performed at 23 (B), 61 (C) and 83 months (D) reveal the stability of the lesion. European Journal of Radiology Open 2018 5, 177-182DOI: (10.1016/j.ejro.2018.09.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 2 Axial MDCT images with lung window (A) and mediastinal window (B) show an irregular consolidation in the left lower lobe (arrows). The pulmonary lesion was surgically removed with histological diagnosis of squamous cell lung cancer (pT3N0M0). European Journal of Radiology Open 2018 5, 177-182DOI: (10.1016/j.ejro.2018.09.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 3 Serial MDCT scans of the growing pGGN. (A) The baseline MDCT shows a pGGN (mean diameter, 12 mm) in the anterior segment of the right upper lobe. The follow-up CT scans performed at 12 (B), 25 (C), 42 (D), 106 (E) and 120 months (F) demonstrate the stepwise progression of the lesion from pGGN to solid nodule. Asterisks, bubbly lucencies; Curved arrows, solid component; Arrowhead, calcifications. European Journal of Radiology Open 2018 5, 177-182DOI: (10.1016/j.ejro.2018.09.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 4 Axial CT (A), axial PET (B) and axial fused PET/CT (C) images show a pathological FDG uptake within the solid component of the nodule with a SUVmax of 4.7. Note mild inflammatory FDG uptake in a subcarinal lymph node. European Journal of Radiology Open 2018 5, 177-182DOI: (10.1016/j.ejro.2018.09.004) Copyright © 2018 The Authors Terms and Conditions

Fig. 5 Mesh plots (A and B) and histogram plots (C and D) demonstrate the different surface morphology (hilly or mountainous) and the different distribution of gray values within the largest cross-sectional areas of the stable and the growing pGGNs. European Journal of Radiology Open 2018 5, 177-182DOI: (10.1016/j.ejro.2018.09.004) Copyright © 2018 The Authors Terms and Conditions