Y. -P. Ding, M. -F. Liang, J. -b. Ye, Q. -h. Liu, C. -h. Xiong, B

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Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection Y.-P. Ding, M.-F. Liang, J.-b. Ye, Q.-h. Liu, C.-h. Xiong, B. Long, W.-b. Lin, N. Cui, Z.-q. Zou, Y.-l. Song, Q.-f. Zhang, S. Zhang, Y.-z. Liu, G. Song, Y.-y. Ren, S.-h. Li, Y. Wang, F.-q. Hou, H. Yu, P. Ding, F. Ye, D.-X. Li, G.-Q. Wang Clinical Microbiology and Infection Volume 20, Issue 11, Pages O870-O878 (November 2014) DOI: 10.1111/1469-0691.12636 Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 1 Dynamic profile of laboratory parameters in 59 patients with acute SFTS (11 severe patients and 48 non-severe cases), every other day, based on days after the onset of illness. Lines indicate the mean values of the study groups. The red lines show the mean level of each parameter in severe cases and the black lines indicate the mean level of each parameter in non-severe cases on different days of illness. Clinical Microbiology and Infection 2014 20, O870-O878DOI: (10.1111/1469-0691.12636) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 2 Comparison of cytokine production in the acute phase of SFTS cases and healthy controls. Cytokines in cluster 1 (a) and cluster 2 (b) were detected in the acute-phase serum samples from SFTS patients and healthy donors by multiplex-microbead immunoassays. The cytokine levels were compared between the 59 patients with the acute phase of SFTS and 30 healthy donors. Each dot shows the cytokine concentration in an individual. Horizontal bars indicate the respective group median. *p <0.05, **p <0.005, ***p <0.001. Abbreviations: GM-CSF, granulocyte colony-stimulating factor; IL, interleukin; tPAI-1, plasminogen activator inhibitor-1; sVCAM-1, soluble vascular cell adhesion molecule-1; sICAM-1, soluble intercellular adhesion molecule-1; IP, interferon-γ inducible protein-10; MCP, monocyte chemotactic protein; PDGF, platelet-derived growth factor. Clinical Microbiology and Infection 2014 20, O870-O878DOI: (10.1111/1469-0691.12636) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 3 The cytokine levels were compared between the 48 non-severe cases and 11 severe cases in the acute phase of SFTSV infection. Each dot shows the cytokine concentration in an individual. Horizontal bars indicate the respective group median. *p <0.05, **p <0.005, ***p <0.001. Abbreviations: MCP, monocyte chemotactic protein; HSP, heat shock protein. Clinical Microbiology and Infection 2014 20, O870-O878DOI: (10.1111/1469-0691.12636) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions

FIG. 4 Dynamic profile of cytokines in 59 patients with acute phase SFTS (11 severe patients and 48 non-severe cases) every other day based on days after the onset of illness. Brown boxes indicate severe patients and blue boxes indicate non-severe cases. Bars indicate the values of the study groups. The red lines show the mean level of each cytokine in the severe cases on different days of illness, while the black lines represent the non-severe cases. Clinical Microbiology and Infection 2014 20, O870-O878DOI: (10.1111/1469-0691.12636) Copyright © 2014 European Society of Clinical Infectious Diseases Terms and Conditions