Volume 175, Issue 1, Pages 6-9 (September 2018)

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Volume 175, Issue 1, Pages 6-9 (September 2018) Histone Modifications: Insights into Their Influence on Gene Expression Bruce Stillman Cell Volume 175, Issue 1, Pages 6-9 (September 2018) DOI: 10.1016/j.cell.2018.08.032 Copyright © 2018 Elsevier Inc. Terms and Conditions

Figure 1 Histone Modifications and Gene Expression Top: Studies in two model organisms, S. cerevisiae and Tetrahymena, resulted in the discovery of the importance of histones in nucleosomes for both activation or repression of gene expression via the discovery of enzymes that can post-translationally modify histones at specific, non-random sites (pictures not to scale). Middle: The histone (H3·H4)2(H2A·H2B)2 core octamer and the histone tails in nucleosomes can be modified at specific sites, and the modification writers can spread these marks to adjacent chromatin. Bottom: Histone modifications can either activate (green) or repress (red) gene transcription. Cell 2018 175, 6-9DOI: (10.1016/j.cell.2018.08.032) Copyright © 2018 Elsevier Inc. Terms and Conditions