Jesús Merayo-Lloves, MD, Tong Z. Zhao, MD, James E. Dutt, BA, C

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Presentation transcript:

A new murine model of allergic conjunctivitis and effectiveness of nedocromil sodium Jesús Merayo-Lloves, MD, Tong Z. Zhao, MD, James E. Dutt, BA, C.Stephen Foster, MD, FACS Journal of Allergy and Clinical Immunology Volume 97, Issue 5, Pages 1129-1140 (May 1996) DOI: 10.1016/S0091-6749(96)70268-3 Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 A, Mouse eye 20 minutes after conjunctival challenge with ragweed pollen. Notice presence of conjunctival edema and redness (arrow). B, Mouse eye treated topically with nedocromil sodium. Notice reduction of conjunctival edema and redness (arrow). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 1 A, Mouse eye 20 minutes after conjunctival challenge with ragweed pollen. Notice presence of conjunctival edema and redness (arrow). B, Mouse eye treated topically with nedocromil sodium. Notice reduction of conjunctival edema and redness (arrow). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Eosinophil infiltration in conjunctival substantia propia closest to epithelium (arrows). PBS-treated group. Mouse conjunctiva (hematoxylin-eosin, ×160). B, Reduction of eosinophil infiltration by nedocromil sodium. Nedocromil-treated group. Mouse conjunctiva (hematoxylin-eosin, ×160). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 2 Eosinophil infiltration in conjunctival substantia propia closest to epithelium (arrows). PBS-treated group. Mouse conjunctiva (hematoxylin-eosin, ×160). B, Reduction of eosinophil infiltration by nedocromil sodium. Nedocromil-treated group. Mouse conjunctiva (hematoxylin-eosin, ×160). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 A, Degranulating mast cells in PBS-treated group (arrows). Mouse conjunctiva (Giemsa, ×256). B, Intact mast cells in nedocromil-treated group (arrows). Mouse conjunctiva (Giemsa, ×256). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 3 A, Degranulating mast cells in PBS-treated group (arrows). Mouse conjunctiva (Giemsa, ×256). B, Intact mast cells in nedocromil-treated group (arrows). Mouse conjunctiva (Giemsa, ×256). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 A, Positive staining for IL-1α in corneal epithelium (arrows). PBS-treated group. Mouse cornea (alkaline phosphatase immunochemical staining, ×160). B, Reduction of IL-1α expression in corneal epithelium in an allergic mouse treated with nedocromil sodium (arrows). Nedocromil-treated group. Mouse cornea (alkaline phosphatase immunochemical staining, ×128). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 4 A, Positive staining for IL-1α in corneal epithelium (arrows). PBS-treated group. Mouse cornea (alkaline phosphatase immunochemical staining, ×160). B, Reduction of IL-1α expression in corneal epithelium in an allergic mouse treated with nedocromil sodium (arrows). Nedocromil-treated group. Mouse cornea (alkaline phosphatase immunochemical staining, ×128). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions

FIG. 5 Macrophages with crystalline proteins from eosinophils (arrow). Mouse conjunctiva. Nedocromil-treated group (TEM, ×16,000). Journal of Allergy and Clinical Immunology 1996 97, 1129-1140DOI: (10.1016/S0091-6749(96)70268-3) Copyright © 1996 Mosby, Inc. Terms and Conditions