Carcinogenesis Bioassays

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Carcinogenesis Bioassays Dose-Response in Female Rats 100.0 90.0 80.0 70.0 liver tumors 60.0 Proportion Responding 50.0 pulmonary tumors 40.0 • clear increase • statistically significant increase 30.0 20.0 10.0 0.0 1 10 100 Dose

Carcinogenesis Bioassays Dose-Response in Female Rats 100.0 mammary gland tumors uterus tumors 90.0 80.0 70.0 60.0 Proportion Responding 50.0 40.0 • clear decrease • statistically significant decrease 30.0 20.0 10.0 0.0 1 10 100 Dose

Carcinogenesis Bioassays Dose-Response in Female Rats 300.0 250.0 200.0 150.0 • overall, not much change • from first, and most influential bioassay of dioxin • carcinogen in female rats? total tumors 100.0 50.0 0.0 1 10 100 Dose