Deconstructing Export of Malaria Proteins

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Deconstructing Export of Malaria Proteins Serge Bonnefoy, Robert Ménard Cell Volume 134, Issue 1, Pages 20-22 (July 2008) DOI: 10.1016/j.cell.2008.06.040 Copyright © 2008 Elsevier Inc. Terms and Conditions

Figure 1 The Malaria Parasite Remodels the Host Erythrocyte After invading the host red blood cell (RBC), the malaria parasite Plasmodium falciparum resides within a parasitophorous vacuole (PV) and induces extensive remodeling of the host erythrocyte. For example, P. falciparum induces the formation of a tubulo-vesicular network (TVN) linked to the PV, as well as flat lamellar membranes called Maurer's clefts that lie below the erythrocyte plasma membrane. The parasite also directs the formation of molecular protuberances (knobs) at the host cell surface that display parasite surface proteins such as PfEMP1, which allow infected erythrocytes to adhere to host endothelial cells through interaction with endothelial receptors. Cell 2008 134, 20-22DOI: (10.1016/j.cell.2008.06.040) Copyright © 2008 Elsevier Inc. Terms and Conditions