Volume 17, Issue 12, Pages 1083-1097 (December 2018) Global, regional, and national burden of motor neuron diseases 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016  Giancarlo Logroscino, Marco Piccininni, Benoît Marin, Emma Nichols, Foad Abd-Allah, Ahmed Abdelalim, Fares Alahdab, Solomon Weldegebreal Asgedom, Ashish Awasthi, Yazan Chaiah, Ahmad Daryani, Huyen Phuc Do, Manisha Dubey, Alexis Elbaz, Sharareh Eskandarieh, Farzaneh Farhadi, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Kyle J. Foreman, Abadi Kahsu Gebre, Elena V. Gnedovskaya, Samer Hamidi, Simon I. Hay, Seyed Sina Naghibi Irvani, John S. Ji, Amir Kasaeian, Yun Jin Kim, Lorenzo Giovanni Mantovani, Tivani Phosa Mashamba-Thompson, Man Mohan Mehndiratta, Ali H. Mokdad, Gabriele Nagel, Trang Huyen Nguyen, Molly R Nixon, Andrew T Olagunju, Mayowa Ojo Owolabi, Michael A Piradov, Mostafa Qorbani, Amir Radfar, Robert C Reiner, Mohammad Ali Sahraian, Shahabeddin Sarvi, Mehdi Sharif, Omar Temsah, Bach Xuan Tran, Nu Thi Truong, Narayanaswamy Venketasubramanian, Andrea Sylvia Winkler, Ebrahim M Yimer, Valery L. Feigin, Theo Vos, Christopher J L Murray Giancarlo Logroscino, Marco Piccininni, Benoît Marin, Emma Nichols, Foad Abd-Allah, Ahmed Abdelalim, Fares Alahdab, Solomon Weldegebreal Asgedom, Ashish Awasthi, Yazan Chaiah, Ahmad Daryani, Huyen Phuc Do, Manisha Dubey, Alexis Elbaz, Sharareh Eskandarieh, Farzaneh Farhadi, Farshad Farzadfar, Seyed-Mohammad Fereshtehnejad, Eduarda Fernandes, Irina Filip, Kyle J. Foreman, Abadi Kahsu Gebre, Elena V. Gnedovskaya, Samer Hamidi, Simon I. Hay, Seyed Sina Naghibi Irvani, John S. Ji, Amir Kasaeian, Yun Jin Kim, Lorenzo Giovanni Mantovani, Tivani Phosa Mashamba-Thompson, Man Mohan Mehndiratta, Ali H. Mokdad, Gabriele Nagel, Trang Huyen Nguyen, Molly R Nixon, Andrew T Olagunju, Mayowa Ojo Owolabi, Michael A Piradov, Mostafa Qorbani, Amir Radfar, Robert C Reiner, Mohammad Ali Sahraian, Shahabeddin Sarvi, Mehdi Sharif, Omar Temsah, Bach Xuan Tran, Nu Thi Truong, Narayanaswamy Venketasubramanian, Andrea Sylvia Winkler, Ebrahim M Yimer, Valery L. Feigin, Theo Vos, Christopher J L Murray  The Lancet Neurology  Volume 17, Issue 12, Pages 1083-1097 (December 2018) DOI: 10.1016/S1474-4422(18)30404-6 Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 1 Age-standardised prevalence of motor neuron disease per 100 000 population by location for both sexes, 2016 ATG=Antigua and Barbuda. FSM=Federated States of Micronesia. Isl=Islands. LCA=Saint Lucia. TLS=Timor-Leste. TTO=Trinidad and Tobago. VCT=Saint Vincent and the Grenadines. The Lancet Neurology 2018 17, 1083-1097DOI: (10.1016/S1474-4422(18)30404-6) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 2 Global prevalence of motor neuron diseases by age and sex, 2016 Prevalence is expressed as the percentage of the population that is affected by the disease. Shaded areas show 95% uncertainty intervals. Values are plotted at the midpoint of 5-year age categories. The Lancet Neurology 2018 17, 1083-1097DOI: (10.1016/S1474-4422(18)30404-6) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 3 Global years lived with disability (YLDs) and years of life lost (YLLs) rates per 100 000 population due to motor neuron diseases by age, 2016 Shaded areas show 95% uncertainty intervals. Values are plotted at the midpoint of 5-year age categories. The Lancet Neurology 2018 17, 1083-1097DOI: (10.1016/S1474-4422(18)30404-6) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions

Figure 4 Age-standardised disability-adjusted-life-year (DALY) rates for motor neuron diseases by 21 Global Burden of Disease regions by Socio-demographic Index (SDI), 1990–2016 The black line represents expected values based on SDI from a regression of all location data over the entire 1990 to 2016 estimation period. The Lancet Neurology 2018 17, 1083-1097DOI: (10.1016/S1474-4422(18)30404-6) Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license Terms and Conditions