Volume 382, Issue 9890, Pages (August 2013)

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Volume 382, Issue 9890, Pages 397-408 (August 2013) Early surgery versus initial conservative treatment in patients with spontaneous supratentorial lobar intracerebral haematomas (STICH II): a randomised trial Prof A David Mendelow, FRCS[SN], Dr Barbara A Gregson, PhD, Elise N Rowan, PhD, Prof Gordon D Murray, PhD, Anil Gholkar, FRCR, Patrick M Mitchell, FRCS The Lancet Volume 382, Issue 9890, Pages 397-408 (August 2013) DOI: 10.1016/S0140-6736(13)60986-1 Copyright © 2013 Mendelow et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 1 Trial profile *One site recruited one patient but had undertaken surgery before randomisation (the patient was allocated to initial conservative treatment); another site recruited three patients, and two of these had surgery before randomisation (one allocated to early surgery and one to initial conservative treatment); because of the severe breach of protocol all four patients were excluded. The Lancet 2013 382, 397-408DOI: (10.1016/S0140-6736(13)60986-1) Copyright © 2013 Mendelow et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 2 Kaplan–Meier survival curve The Lancet 2013 382, 397-408DOI: (10.1016/S0140-6736(13)60986-1) Copyright © 2013 Mendelow et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 3 Extended Glasgow Outcome Scale at 6 months Proportional odds model p=0·075. The Lancet 2013 382, 397-408DOI: (10.1016/S0140-6736(13)60986-1) Copyright © 2013 Mendelow et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 4 Subgroup analysis Forest plot GCS=Glasgow Coma Score. The Lancet 2013 382, 397-408DOI: (10.1016/S0140-6736(13)60986-1) Copyright © 2013 Mendelow et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions

Figure 5 Updated meta-analysis of 15 trials of surgery in patients with intracerebral haemorrhage (A) and individual patient data in cases of lobar haematomas without intraventricular haemorrhage (B) Data are n/N, unless otherwise indicated. Reported outcomes were unfavourable outcome in (A) and death or disability in (B). df=degrees of freedom. The Lancet 2013 382, 397-408DOI: (10.1016/S0140-6736(13)60986-1) Copyright © 2013 Mendelow et al. Open Access article distributed under the terms of CC BY-NC-ND Terms and Conditions