Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle Jonathan.

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Contrasting Localization of c-Myc with Other Myc Superfamily Transcription Factors in the Human Hair Follicle and During the Hair Growth Cycle Jonathan J. Bull, Sven Mïller-Röver, Sejal V. Patel, Catherine M.T. Chronnell, Ian A. McKay, Michael P. Philpott Journal of Investigative Dermatology Volume 116, Issue 4, Pages 617-622 (April 2001) DOI: 10.1046/j.1523-1747.2001.12771234.x Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Immunohistochemical analysis reveals that Myc superfamily transcription factors are located in key regions of the human hair follicle. Positive staining is shown in red, whereas hematoxylin counterstaining is in blue. Parts (a) and (b) show the bulge region in anagen, stained for c -Myc and C8/144B epitope, respectively (brackets denote stained bulge region), whereas parts (c) and (d) show serial sections of the bulge region at higher magnification, stained for c-Myc and C8/144B epitope, respectively. (e) c-Myc staining of individual cells within the bulge (arrowheads show c-Myc negative cells with in the C8/144B-positive bulge region). (f–i) c-Myc in (f) bulge of a vellus hair follicle; (g) interfollicular epidermis and infundibulum; (h) follicle bulb; (i) proximal region of telogen follicle. The staining patterns in the human hair follicle are shown for Mad1 (j–k); Mad3 (l–o); N-Myc (p–s); Max (t–w). Staining for c-Myc, Mad1, Mad3, N-Myc, and Max in (g, l, p, t), interfollicular epidermis and infundibulum (a, m, q, u) bulge region of anagen follicles (h, j, n, r, v) follicle bulb (i, k, o, s, w) proximal region of a telogen follicle, is illustrated. Double staining for c-Myc and Ki67 is shown in the central hair follicle (x) and follicle bulb (y). Ki67-positive cells are stained dark brown. Scale bars: (a, b, q, s, y) 140 µm; (c, d, h, j) 60 µm; (e) 40 µm; (f, n) 50 µm; (g, i, k, o, u) 120 µm; (r, v, y) 100 µm; (l, p, t) 110 µm; (m, w) 150 ìm. dashed line define the borders of APM, ORS, and SG not clearly visible. In (k), (o), and (w) dashed circles denote location of DP. In (x) arrows show Ki67-positive ORS cells. APM arrector pilli muscle; B, bulge; CTS connective tissue sheath; DP dermal papilla, E, epidermis; HC, hair canal; HS, hair shaft; HM, hair matrix; INF, infundibulum; ORS, outer root sheath; SG, sebaceous gland. Journal of Investigative Dermatology 2001 116, 617-622DOI: (10.1046/j.1523-1747.2001.12771234.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Summary diagram of the localization of Myc superfamily transcription factors in the human hair follicle. Schematic representation of c-Myc, N-Myc, Max, Mad1, and Mad3 immunoreactivity in the epithelium of human anagen hair follicles. B, bulge; E, epidermis; HM, hair matrix; ORS, outer root sheath. Journal of Investigative Dermatology 2001 116, 617-622DOI: (10.1046/j.1523-1747.2001.12771234.x) Copyright © 2001 The Society for Investigative Dermatology, Inc Terms and Conditions