Exploration of the mechanisms by which 3,4-benzopyrene promotes angiotensin II- induced abdominal aortic aneurysm formation in mice Kangting Ji, MD, Yong.

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Presentation transcript:

Exploration of the mechanisms by which 3,4-benzopyrene promotes angiotensin II- induced abdominal aortic aneurysm formation in mice Kangting Ji, MD, Yong Zhang, PhD, Fengchun Jiang, MD, Lu Qian, MD, Huihui Guo, MD, Jianjian Hu, MD, Lianming Liao, PhD, Jifei Tang, MD, PhD Journal of Vascular Surgery Volume 59, Issue 2, Pages 492-499 (February 2014) DOI: 10.1016/j.jvs.2013.03.022 Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 1 Gross morphology and incidence of abdominal aortic aneurysms (AAAs). Representative photographs show aortas of (A) control mice, without AAAs, and the macroscopic features of AAAs (arrow) induced by (B) angiotensin (Ang) II, (C) 3,4-benzopyrene (BaP), and (D) Ang II plus BaP. No animals infused with medium-chain triglycerides or BaP developed aneurysms. E, Ang II-induced AAA size was markedly increased in mice receiving BaP. ★P < .01 vs control group; ■P < .05 vs Ang II group; ▼P < .01 vs BaP group. F, Incidence of aneurysms expressed as percentage of animals in Ang II and Ang II/BaP group. The incidence of aneurysm was markedly increased in the Ang II/BaP group compared with the Ang II group. ■P < .05 Ang II/BaP vs Ang II group. The error bars show the standard error of the mean. Journal of Vascular Surgery 2014 59, 492-499DOI: (10.1016/j.jvs.2013.03.022) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 2 Angiotensin (Ang) II-induced collage loss, vascular disorganization, and macrophage infiltration were prominently increased in mice receiving coadministration of 3,4-benzopyrene (BaP). Abdominal aortic tissues were harvested, and transversal sections were prepared and stained as described. Representative photomicrographs (original magnification, ×40) are shown from (A, E, I) control animals and animals treated with (B, F, J) Ang II, (C, G, K) BaP, or (D, H, L) Ang II/BaP. A-D, Masson staining. E-H, Hematoxylin and eosin (HE) staining. I-L, Macrophage infiltration. Journal of Vascular Surgery 2014 59, 492-499DOI: (10.1016/j.jvs.2013.03.022) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 3 Angiotensin (Ang) II-induced expression of matrix metalloproteinases (MMPs), nuclear factor (NF)-κB, and apoptosis were prominently increased in mice receiving coadministration of 3,4-benzopyrene (BaP). Abdominal aortic tissues were harvested, and transversal sections were prepared and stained as described. Representative photomicrographs are shown from (A, E, I, M, Q) control animals and animals treated with (B, F, J, N, R) Ang II, (C, G, K, O, S) BaP, or (D, H, L, P, T) Ang II/BaP. A-D, MMP-2 (original magnification, ×40). E-H, MMP-9 (original magnification, ×40). I-L, MMP-12 (original magnification, ×40). M-P, NF-κB (original magnification, ×40). Q-T, Apoptosis (original magnification, ×20). See Fig 4 for quantitative analysis of the result. Journal of Vascular Surgery 2014 59, 492-499DOI: (10.1016/j.jvs.2013.03.022) Copyright © 2014 Society for Vascular Surgery Terms and Conditions

Fig 4 Densitometric quantification of expression of (A) matrix metalloproteinase (MMP)-2, (B) MMP-9, (C) MMP-12, (D) nuclear factor (NF)-κB, and (E) apoptosis in the control group and in animals treated with angiotensin (Ang) II, 3,4-benzopyrene (BaP), or Ang II and BaP combined (n = 12 per group). ★P < .01 vs control group; ▲P < .01 and ■P < .05 vs Ang II group; ▼P < .01 and ●P < .05 vs BaP group. The error bars show the standard error of the mean. Journal of Vascular Surgery 2014 59, 492-499DOI: (10.1016/j.jvs.2013.03.022) Copyright © 2014 Society for Vascular Surgery Terms and Conditions