One single dose of histidine–tryptophan–ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive.

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Presentation transcript:

One single dose of histidine–tryptophan–ketoglutarate solution gives equally good myocardial protection in elective mitral valve surgery as repetitive cold blood cardioplegia: A prospective randomized study Bjørn Braathen, MD, Anders Jeppsson, MD, PhD, Henrik Scherstén, MD, PhD, Ole M. Hagen, MD, Øystein Vengen, MD, PhD, Helena Rexius, MD, PhD, Vincenzo Lepore, MD, PhD, Theis Tønnessen, MD, PhD The Journal of Thoracic and Cardiovascular Surgery Volume 141, Issue 4, Pages 995-1001 (April 2011) DOI: 10.1016/j.jtcvs.2010.07.011 Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 1 A, Maximum postoperative CK-MB with blood and HTK cardioplegia (P = .80). B, Maximum postoperative troponin-T with blood and HTK cardioplegia (P = .60). Values are mean ± standard error of the mean. CK-MB, Creatine kinase isoenzyme MB; HTK, histidine–tryptophan–ketoglutarate. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 995-1001DOI: (10.1016/j.jtcvs.2010.07.011) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 2 A, Creatine kinase isoenzyme MB preoperatively and 7, 20, 44, and 68 hours postoperatively (P = .65 between groups). B, Troponin-T preoperatively and 7, 20, 44, and 68 hours postoperatively (P = .30 between groups). Values are mean ± standard error of the mean. CK-MB, Creatine kinase isoenzyme MB; HTK, histidine–tryptophan–ketoglutarate; Preop, preoperatively; PO, postoperatively. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 995-1001DOI: (10.1016/j.jtcvs.2010.07.011) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions

Figure 3 A and B, No correlation between cardiac enzymes and crossclamp time in the group of patients receiving cold blood cardioplegia. C and D, Positive correlation between cardiac enzymes and crossclamp time in the group of patients receiving HTK cardioplegia. Dashed lines show 95% confidence and prediction intervals. CK-MB, Creatine kinase isoenzyme MB; HTK, histidine–tryptophan–ketoglutarate. The Journal of Thoracic and Cardiovascular Surgery 2011 141, 995-1001DOI: (10.1016/j.jtcvs.2010.07.011) Copyright © 2011 The American Association for Thoracic Surgery Terms and Conditions