YAPping About Glutaminolysis in Hepatic Fibrosis Lloyd D. Harvey  Gastroenterology  Volume 154, Issue 5, Pages 1231-1233 (April 2018) DOI: 10.1053/j.gastro.2018.03.007 Copyright © 2018 AGA Institute Terms and Conditions

Figure 1 A Yes-associated protein (YAP)–glutaminase axis mediates hepatic stellate cell transdifferentiation and liver fibrosis. Du et al present findings demonstrating that Hedgehog signaling mediates the up-regulation of glutaminase via a downstream mediator YAP of the Hippo signaling pathway. Up-regulation of glutaminase, an anaplerotic reaction that replenishes metabolic intermediates, such as α-ketoglutarate, sustains increased bioenergetic and biomass requirements of proliferating cells. Glutaminolysis has a critical role in the transdifferentiation of hepatic stellate cells into myofibroblasts, demonstrating increased proliferative, migratory, and fibrogenic capacities in the manifestation of liver fibrosis. Novel therapeutic and diagnostic strategies could be envisioned based on these molecular findings. TCA, tricarboxylic acid. Gastroenterology 2018 154, 1231-1233DOI: (10.1053/j.gastro.2018.03.007) Copyright © 2018 AGA Institute Terms and Conditions