The Many Faces of PPARγ Cell

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The Many Faces of PPARγ Cell Michael Lehrke, Mitchell A. Lazar Cell Volume 123, Issue 6, Pages 993-999 (December 2005) DOI: 10.1016/j.cell.2005.11.026 Copyright © 2005 Elsevier Inc. Terms and Conditions

Figure 1 The Many Faces of PPARγ PPARγ has many activities, leading to complicated and even paradoxical effects on adipocyte biology, insulin action, cardiovascular disease, inflammation, renal function, and tumor biology. Shown are some of the various tissues and processes that PPAR affects. The specific gene targets are discussed in the text. The ultimate therapeutic potential of small molecule regulators depends upon their ability to selectively modulate PPARγ activity in a gene- and tissue-specific manner. Cell 2005 123, 993-999DOI: (10.1016/j.cell.2005.11.026) Copyright © 2005 Elsevier Inc. Terms and Conditions