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Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.176 Figure 5 Simplified T‑cell differentiation pathways involving rheumatoid arthritis-risk loci gene products Figure 5 | Simplified T-cell differentiation pathways involving rheumatoid arthritis-risk loci gene products. Thirteen rheumatoid arthritis- risk loci gene products (red) are mapped to simplified signalling pathways involved in T-cell differentiation. CCR6, C-C chemokine receptor type 6; CXCR5, C-X-C chemokine receptor type 5; FOXP3, forkhead box protein P3; GATA3, trans-acting T-cell-specific transcription factor GATA3; IFNGR, interferon γ receptor; IL-4R, interleukin-4 receptor; IL-6R, interleukin-6 receptor; IL-10R, interleukin-10 receptor; IL-21R, interleukin-21 receptor; IRF4, interferon regulatory factor 4; RORγT, nuclear receptor RORγT; SHP2, tyrosine-protein phosphatase non-receptor type 11; STAT, signal transducer and activator of transcription; T-bet, T-box transcription factor TBX21; TFH cell, follicular helper T cell; TGFβ, transforming growth factor β; TGFβR, transforming growth factor β receptor; TH cell, helper T cell; TNFR, TNF receptor; Treg cell, regulatory T cell; TYK2, non-receptor tyrosine-protein kinase TYK2. Kim, K. et al. (2016) Update on the genetic architecture of rheumatoid arthritis Nat. Rev. Rheumatol. doi:10.1038/nrrheum.2016.176