SP and KLF Transcription Factors in Digestive Physiology and Diseases Chang-Kyung Kim, Ping He, Agnieszka B. Bialkowska, Vincent W. Yang  Gastroenterology  Volume 152, Issue 8, Pages 1845-1875 (June 2017) DOI: 10.1053/j.gastro.2017.03.035 Copyright © 2017 AGA Institute Terms and Conditions

Figure 1 Structure of human SP and KLF proteins. The A, B, C, and D define the modules of SP1. AD, activation; RD, repression domain; TAD, transactivation (reviewed in Kaczynski et al,2 Bouwman and Philipsen,3 Lomberk and Urrutia,4 McConnell and Yang,5 and Lomberk et al6). The accession numbers of proteins used for this figure are listed per UniProtKB database as follows: SP1 (P08047), SP2 (Q02086), SP3 (Q02447), SP4 (Q02446), SP5 (Q6BEB4), SP6 (Q3SY56), SP7 (Q87DD2), SP8 (Q8IXZ3), SP9 (P0CG40), KLF1 (Q13351), KLF2 (Q9Y5W3), KLF3 (P57682), KLF4 (O43474), KLF5 (Q13887), KLF6 (Q99612), KLF7 (O75840), KLF8 (O95600), KLF9 (Q13886), KLF10 (Q13118), KLF11 (O14901), KLF12 (Q9Y4X4), KLF13 (Q9Y2Y9), KLF14 (Q8TD94), KLF15 (Q9UIH9), KLF16 (Q9BXK1), and KLF17 (Q5JT82). Adapted with permission from Bouwman and Philipsen.3 Gastroenterology 2017 152, 1845-1875DOI: (10.1053/j.gastro.2017.03.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 2 Post-translational modifications and co-factors that interact with SP and KLF proteins. SP/KLF protein is illustrated as a bar with the 3 zinc fingers identified near the carboxyl terminus. The various post-translational modifications are described above the protein and the various co-activators or co-repressors that interact with the protein below. HDAC, histone deacetylase; TF, transcription factor. Gastroenterology 2017 152, 1845-1875DOI: (10.1053/j.gastro.2017.03.035) Copyright © 2017 AGA Institute Terms and Conditions

Figure 3 Expression patterns of SP and KLF proteins under physiologic conditions in the digestive system. The diagram illustrates the various organs or tissues in the digestive system, including the oral mucosa, esophagus, stomach, small intestine, colon, liver, and pancreas. Various members of SP and KLF proteins found in the given tissues or cell types are included in the figure. SMC, smooth muscle cell. Gastroenterology 2017 152, 1845-1875DOI: (10.1053/j.gastro.2017.03.035) Copyright © 2017 AGA Institute Terms and Conditions