Volume 119, Issue 1, Pages 15-22 (July 2000) Surrogate markers of intestinal inflammation are predictive of relapse in patients with inflammatory bowel disease  Jeremy A Tibble, Gudmundur Sigthorsson, Steven Bridger, Magne K. Fagerhol, Ingvar Bjarnason  Gastroenterology  Volume 119, Issue 1, Pages 15-22 (July 2000) DOI: 10.1053/gast.2000.8523 Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 1 Receiver operator curve for fecal calprotectin in predicting relapse of disease in all patients with inflammatory bowel disease (CD and UC). The value of fecal calprotectin that gives the maximal sum of (sensitivity) + (specificity) is 50 mg/L. Gastroenterology 2000 119, 15-22DOI: (10.1053/gast.2000.8523) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 2 Kaplan–Meier time to relapse curves for patients with CD and patients with UC in relation to fecal calprotectin. In both disease groups there is a significant difference (P < 0.0001, log rank) in the proportion of patients who relapsed over a 12-month period depending on the fecal calprotectin concentration (> or <50 mg/L) at time of inclusion into the study. Gastroenterology 2000 119, 15-22DOI: (10.1053/gast.2000.8523) Copyright © 2000 American Gastroenterological Association Terms and Conditions

Fig. 3 Kaplan–Meier time to relapse curves for patients with CD with small intestinal involvement in relation to the lactulose/L-rhamnose intestinal permeability ratio. There is a significant difference (P < 0.005, log rank) in the proportion of patients who relapsed over a 12-month period depending on the lactulose/L-rhamnose intestinal permeability ratio (> or <0.05) at the time of inclusion into the study. Gastroenterology 2000 119, 15-22DOI: (10.1053/gast.2000.8523) Copyright © 2000 American Gastroenterological Association Terms and Conditions