Mitochondrial membrane perturbations in cholestasis

Slides:

Advertisements

Similar presentations

Apoptosis By Douglas R. Green

Advertisements

Mechanisms of Bcl-2 in Programmed Cell Death Laura Beth Hill St. Edward’s University.

Mitochondrial Permeability Transition Pore Gao Qin.

Mechanisms of Bcl-2 in Programmed Cell Death Laura Beth Hill St. Edward’s University.

EASL Clinical Practice Guidelines: Vascular diseases of the liver Journal of Hepatology Volume 64, Issue 1, Pages (January 2016) DOI: /j.jhep

Omega 3 – Omega 6: What is right for the liver? Ashraf Mohammad El-Badry, Rolf Graf, Pierre-Alain Clavien Journal of Hepatology Volume 47, Issue 5, Pages.

Volume 128, Issue 1, Pages (January 2005)

Inflammasomes in liver diseases

Lifestyle interventions for the treatment of non-alcoholic fatty liver disease in adults: A systematic review Christian Thoma, Christopher P. Day, Michael.

Hepatic CD141+IFNλ+ DC subset: One against all?

Cell death in cartilage

Ulrich Beuers, Michael Trauner, Peter Jansen, Raoul Poupon

Volume 130, Issue 1, Pages (January 2006)

Hepatitis induced by Kava (Piper methysticum rhizoma)

Anatoliy I. Masyuk, Tatyana V. Masyuk, Nicholas F. LaRusso

Atsushi Tanaka, Richard J. Youle Molecular Cell

Matthew T. Kitson, Stuart K. Roberts Journal of Hepatology

Study may improve survival of transplanted livers

Model for mitosis‐induced apoptosis.

Tocotrienols Induce Apoptosis and Autophagy in Rat Pancreatic Stellate Cells Through the Mitochondrial Death Pathway Mariana Rickmann, Eva C. Vaquero,

Volume 44, Issue 6, Pages (June 2006)

Volume 42, Issue 3, Pages (March 2005)

Uncoupling proteins and non-alcoholic fatty liver disease

Leptin, obesity, and liver disease

Peptides Signal Mitochondrial Stress

How cells die: Apoptosis pathways

Keiji Hirata, Michael H. Nathanson Gastroenterology

Endoplasmic reticulum stress in liver disease

Cathepsin-B-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism of T-cell depletion by Marie-Cécile Michallet, Frederic Saltel,

Living donor liver transplantation: is the hype over?

Volume 96, Issue 10, Pages (May 2009)

UVA1 Radiation Triggers Two Different Final Apoptotic Pathways

Hepatitis C core protein – The “core” of immune deception?

Benjamin L. Woolbright, Hartmut Jaeschke Journal of Hepatology

Gliotoxin-mediated apoptosis of activated human hepatic stellate cells

Advancing hepatitis B virus entry inhibitors

Possible mechanisms of Cyclosporin A ameliorated the ischemic microenvironment and inhibited mitochondria stress in tree shrews’ hippocampus Shu-qing.

Joshua E. Allen, Wafik S. El-Deiry Gastroenterology

Roger Schneiter, Sepp D Kohlwein Cell

The intrinsic apoptotic pathway is a balance between proapoptotic proteins, for example, Bax and Bak and antiapoptotic proteins. The intrinsic apoptotic.

Volume 14, Issue 3, Pages (December 2007)

Volume 69, Issue 4, Pages (October 2018)

Volume 102, Issue 1, Pages 1-4 (July 2000)

Bax Activation and Induction of Apoptosis in Human Keratinocytes by the Protein Kinase C δ Catalytic Domain Leonid A. Sitailo, Shalini S. Tibudan, Mitchell.

Mitochondria: important target for drug toxicity?

Oxidative stress and mitochondrial dysfunction in sepsis

Apoptosis and acute kidney injury

Volume 69, Issue 6, Pages (December 2018)

Remodeling for Demolition

Dangerous Liaisons: Mitochondrial DNA Meets the NLRP3 Inflammasome

Inhibition of bile salt-induced apoptosis by cyclic AMP involves serine/threonine phosphorylation of CD95 Roland Reinehr, Dieter Häussinger Gastroenterology

Apoptotic insults to human HepG2 cells induced by S-(+)-ketamine occurs through activation of a Bax-mitochondria-caspase protease pathway S.-T. Lee,

Death receptor-mediated apoptosis and the liver

Volume 72, Issue 8, Pages (October 2007)

Manipulation of Host Cell Death Pathways during Microbial Infections

Table of contents The Journal for Nurse Practitioners

Arnaud Autret, Seamus J. Martin Molecular Cell

Moshi Song, Gerald W. Dorn Cell Metabolism

Pathogenesis of cholestatic hepatitis C

Advances in the pathogenesis of HIV-associated kidney diseases

Apoptosis: Current Biology

Volume 77, Issue 10, Pages (May 2010)

Mauro Maccarrone, Massimo Taccone-Gallucci, Alessandro Finazzi-Agrò

Study may improve survival of transplanted livers

Impact of anaesthetics and surgery on neurodevelopment: an update

The End and After: How Dying Cells Impact the Living Organism

Jean-Claude Martinou, Richard J. Youle Developmental Cell

Lesley-Ann Martin, Mitch Dowsett Cancer Cell

Dulguun Amgalan et al. BTS 2017;2:

Volume 44, Issue 5, Pages (May 2006)

Presentation transcript:

Mitochondrial membrane perturbations in cholestasis Cecília M.P Rodrigues, Clifford J Steer Journal of Hepatology Volume 32, Issue 1, Pages 135-141 (January 2000) DOI: 10.1016/S0168-8278(00)80200-7

Fig. 1 Electron microscopy of isolated rat liver mitochondria incubated with either deoxycholic acid (DCA), UDCA, DCA plus UDCA, cyclosporine A (CsA), DCA plus CsA, or no addition (control). Deoxycholic acid induces morphologic changes associated with MPT in isolated mitochondria. UDCA and cyclosporine A inhibit deoxycholic acid-induced morphologic changes in isolated mitochondria after MPT (from reference 73). Magnification 25 000⨯. Journal of Hepatology 2000 32, 135-141DOI: (10.1016/S0168-8278(00)80200-7)

Fig. 2 Proposed model for bile acid-induced mitochondrial alterations during cholestasis. Hydrophobic bile acids such as deoxycholic acid can trigger mitochondria to release caspase-activating proteins. Cytochrome c and other proteins are released from the intermembrane space of mitochondria into the cytosol after organelle swelling and subsequent rupture of the outer membrane. In addition, efflux can also occur through channel opening without morphologic alterations. See text for more complete discussion. Journal of Hepatology 2000 32, 135-141DOI: (10.1016/S0168-8278(00)80200-7)