Volume 81, Issue 11, Pages (June 2012)

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Volume 81, Issue 11, Pages 1108-1115 (June 2012) Dialysis outcomes and analysis of practice patterns suggests the dialysis schedule affects day-of-week mortality Hui Zhang, Douglas E. Schaubel, John D. Kalbfleisch, Jennifer L. Bragg-Gresham, Bruce M. Robinson, Ronald L. Pisoni, Bernard Canaud, Michel Jadoul, Takashi Akiba, Akira Saito, Friedrich K. Port, Rajiv Saran Kidney International Volume 81, Issue 11, Pages 1108-1115 (June 2012) DOI: 10.1038/ki.2011.481 Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 1 Distribution of deaths by day of the week for patients receiving dialysis on Monday–Wednesday–Friday (MWF) and Tuesday–Thursday–Saturday (TTS). (a) For MWF schedule patients, Monday had a much higher percentage of deaths for the US and European patients. (b) For TTS schedule patients, Tuesday had the highest percentage of deaths for the US and Japanese patients. Kidney International 2012 81, 1108-1115DOI: (10.1038/ki.2011.481) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 2 Relative risk of mortality (all-cause) by day. (a) US patients receiving dialysis on Monday–Wednesday–Friday (MWF). Covariate-adjusted hazard ratios (HRs) of all-cause mortality by day of the week with MWF schedule for US patients. The reference is the average of 7 days of the week. The asterisks (*) mean that the effect is significant. (b) European patients receiving dialysis on MWF. Covariate-adjusted HRs of all-cause mortality by day of the week with MWF schedule for European patients. (c) Japanese patients receiving dialysis on MWF. Covariate-adjusted HRs of all-cause mortality by day of the week with MWF schedule for Japanese patients. Kidney International 2012 81, 1108-1115DOI: (10.1038/ki.2011.481) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 3 Relative risk of mortality (all-cause) by day. (a) US patients receiving dialysis on Tuesday–Thursday–Saturday (TTS). Covariate-adjusted hazard ratios (HRs) of all-cause mortality by day of the week with TTS schedule for US patients. The reference is the average of 7 days of the week. The asterisks (*) mean that the effect is significant. (b) European patients receiving dialysis on TTS. Covariate-adjusted HRs of all-cause mortality by day of the week with TTS schedule for European patients. (c) Japanese patients receiving dialysis on TTS. Covariate-adjusted HRs of all-cause mortality by day of the week with TTS schedule for Japanese patients. Kidney International 2012 81, 1108-1115DOI: (10.1038/ki.2011.481) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 4 Relative risk of mortality (cardiovascular disease (CVD) and non-CVD) by day. (a) US patients receiving dialysis on Monday–Wednesday–Friday (MWF). Covariate-adjusted hazard ratios (HRs) of CVD and non-CVD mortality by day of the week with MWF schedule for US patients. The reference is the average of 7 days of the week. The asterisks (*) mean that the effect is significant. (b) European patients receiving dialysis on MWF. Covariate-adjusted HRs of CVD and non-CVD mortality by day of week with MWF schedule for European patients. (c) Japanese patients receiving dialysis on MWF. Covariate-adjusted HRs of CVD and non-CVD mortality by day of the week with MWF schedule for Japanese patients. Kidney International 2012 81, 1108-1115DOI: (10.1038/ki.2011.481) Copyright © 2012 International Society of Nephrology Terms and Conditions

Figure 5 Relative risk of mortality (cardiovascular disease (CVD) and non-CVD) by day. (a) US patients receiving dialysis on Tuesday–Thursday–Saturday (TTS). Hazard ratios (HRs) of CVD and non-CVD mortality by day of the week with TTS schedule for US patients. The reference is the average of 7 days of the week. The asterisks (*) mean that the effect is significant. (b) European patients receiving dialysis on TTS. HRs of CVD and non-CVD mortality by day of week with TTS schedule for European patients. (c) Japanese patients receiving dialysis on TTS. HRs of CVD and non-CVD mortality by day of the week with TTS schedule for Japanese patients. Kidney International 2012 81, 1108-1115DOI: (10.1038/ki.2011.481) Copyright © 2012 International Society of Nephrology Terms and Conditions