Aortic Root Replacement With Biological Valved Conduits

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Aortic Root Replacement With Biological Valved Conduits Sebastiano Castrovinci, MD, David H. Tian, BS, Giacomo Murana, MD, Mariano Cefarelli, MD, Paolo Berretta, MD, Jacopo Alfonsi, MD, Tristan D. Yan, MD, PhD, Roberto Di Bartolomeo, MD, Marco Di Eusanio, MD, PhD The Annals of Thoracic Surgery Volume 100, Issue 1, Pages 337-353 (July 2015) DOI: 10.1016/j.athoracsur.2015.02.057 Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Search strategy of systematic review on Bentall operation using biological valved conduit. From Moher D, Liberati A, Tetzlaff J, Altman DG. The PRISMA flow-chart [8]. The Annals of Thoracic Surgery 2015 100, 337-353DOI: (10.1016/j.athoracsur.2015.02.057) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Overall survival based on reconstructed individual patient data. Data of 1,882 patients from 15 studies were reconstructed and presented. Dotted lines represent Kaplan-Meier curves of individual studies, and the solid line represents aggregated survival data of the 15 included studies. Numbers within the figure represent the study reference from which the corresponding curve was reconstructed. The Annals of Thoracic Surgery 2015 100, 337-353DOI: (10.1016/j.athoracsur.2015.02.057) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 Freedom from reoperation based on reconstructed individual patient data. Data of 1,216 patients from 10 studies were reconstructed and presented. Dotted lines represent Kaplan-Meier curves of individual studies, and the solid line represents aggregated survival data of the 10 included studies. Numbers within the figure represent the study reference from which the corresponding curve was reconstructed. The Annals of Thoracic Surgery 2015 100, 337-353DOI: (10.1016/j.athoracsur.2015.02.057) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 4 Freedom from thromboembolic events based on reconstructed individual patient data. Data of 361 patients from 3 studies were reconstructed and presented. Dotted lines represent Kaplan-Meier curves of individual studies, and the solid line represents aggregated survival data of the 3 included studies. Numbers within the figure represent the study reference from which the corresponding curve was reconstructed. The Annals of Thoracic Surgery 2015 100, 337-353DOI: (10.1016/j.athoracsur.2015.02.057) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 5 Freedom from endocarditis based on reconstructed individual patient data. Data of 631 patients from 3 studies were reconstructed and presented. Dotted lines represent Kaplan-Meier curves of individual studies, and the solid line represents aggregated survival data of the 3 included studies. Numbers within the figure represent the study reference from which the corresponding curve was reconstructed. The Annals of Thoracic Surgery 2015 100, 337-353DOI: (10.1016/j.athoracsur.2015.02.057) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 6 Funnel plot for systematic review of Bentall procedures using biological roots. The logit event rate for mortality (horizontal axis) is presented against the standard error of the log of the logit event rate (vertical axis). The standard error inversely corresponds to the study size. Asymmetry of the plot can indicate publication bias. Open circles indicate included studies, and filled circles represent imputed studies identified through Trim and Fill analysis. The Annals of Thoracic Surgery 2015 100, 337-353DOI: (10.1016/j.athoracsur.2015.02.057) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions

Fig 7 Temporal trend of biological Bentall cases. The number of cases per year is averaged over the duration of each study. Each bar is subdivided into the contributions of individual studies. For example, in 2010, there were 3 studies with data presented. Color scheme identifies individual studies across the study period. The Annals of Thoracic Surgery 2015 100, 337-353DOI: (10.1016/j.athoracsur.2015.02.057) Copyright © 2015 The Society of Thoracic Surgeons Terms and Conditions