Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta- analysis of randomized placebo-controlled trials E.M. Bartels,

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Presentation transcript:

Symptomatic efficacy and safety of diacerein in the treatment of osteoarthritis: a meta- analysis of randomized placebo-controlled trials E.M. Bartels, H. Bliddal, P.K. Schøndorff, R.D. Altman, W. Zhang, R. Christensen Osteoarthritis and Cartilage Volume 18, Issue 3, Pages 289-296 (March 2010) DOI: 10.1016/j.joca.2009.10.006 Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 1 Flow chart showing the search strategy and further selection of trials. Osteoarthritis and Cartilage 2010 18, 289-296DOI: (10.1016/j.joca.2009.10.006) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 2 Efficacy forest plot of trials comparing diacerein with placebo in OA patients presented as SMDs for (A) pain and (B) disability. Every square represents the individual study's effect measure with 95% CI indicated by horizontal lines. Square sizes are proportional to the precision of the estimate. The overall estimate from the meta-analysis and its CI are shown at the bottom of each subplot, represented as a diamond (random-effects model). Osteoarthritis and Cartilage 2010 18, 289-296DOI: (10.1016/j.joca.2009.10.006) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 3 ESs as a function of study duration. ESs on the vertical axis are plotted against the study duration on the horizontal axis. Size of every circle is proportional to the precision of each efficacy estimate. The solid line indicates the predicted treatment magnitude and direction; using an REML-based model. Osteoarthritis and Cartilage 2010 18, 289-296DOI: (10.1016/j.joca.2009.10.006) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions

Fig. 4 Safety forest plot of trials comparing diacerein with placebo in OA patients presented as RR's for (A) diarrhea and (B) withdrawal due to any adverse events. Every square represents the individual study's effect measure with 95% CI indicated by horizontal lines. Square sizes are proportional to the precision of the estimate. The overall estimate from the meta-analysis and its CI are shown at the bottom of each subplot, represented as a diamond (random-effects model). Osteoarthritis and Cartilage 2010 18, 289-296DOI: (10.1016/j.joca.2009.10.006) Copyright © 2009 Osteoarthritis Research Society International Terms and Conditions