Morphological Approach to Hair Disorders

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Morphological Approach to Hair Disorders Rodney Sinclair, Damian Jolley, Rica Mallari, Jill Magee, Antonella Tosti, Bianca Maria Piracinni, C. Vincenzi, Rudolf Happle, Juan Ferrando, Ramon Grimalt, Leroy Thérèse, Dominique Van Neste, Abraham Zlotogorski, Angela M. Christiano, David Whiting Journal of Investigative Dermatology Symposium Proceedings Volume 8, Issue 1, Pages 56-64 (June 2003) DOI: 10.1046/j.1523-1747.2003.12172.x Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 1 Hypotrichosis on the left parietal region with short pigmented hairs. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 2 Yellow-brown hyperpigmentation following the Blaschko's lines. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 3 Hair bulb: The dermal papilla is surrounded by successive layers of hair matrix cells with melanocytes, inner root sheath with unkeratinized Huxley's layer and the outer keratinizing layer of Henle, external root sheath (trichilemma), hyaline membrane, and fibrous sheath. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 4 Upper half of lower follicle: Hair shaft is surrounded by fully keratinized, inner root sheath encircled by outer root sheath (trichilemma). Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 5 Isthmus: The greyish, inner root sheath fragments and disappears and is replaced by pinkish trichilemmal keratin. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 6 Telogen hair: In vertical section, the telogen club with its sac of trichilemmal keratin has retracted upwards, trailing trichilemma, dermal papilla and follicular streamer (stela) below. The horizontal section shows the irregular island of basaloid cells which represents the telogen germinal unit. Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 7 Effect of contrast enhancement on total hair density in control and AGA subjects (groups I–V). Total hair density (all visible hair/cm2; mean±SD) is measured without CE (white bars) and with CE (gray bars) in top of head (left panel) and occipital sites (right panel). Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 8 Total and anagen hair counts in control and AGA subjects (groups I–V). Total (hatched bars) and anagen (gray bars) hair density (n hair/cm2; mean±SD) are measured after contrast enhancement in top of head (left panel) and occipital sites (right panel). Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions

Figure 9 Proportion of thin hair (Ø≤40 μm) in top of the head sites of AGA subjects (groups I–V). The percentage of thin hair (mean±SD) is measured with two distinct methods: evaluation with a ruler on CE-PTG (gray bars) and microscopy on clipped hair (hatched bars). Journal of Investigative Dermatology Symposium Proceedings 2003 8, 56-64DOI: (10.1046/j.1523-1747.2003.12172.x) Copyright © 2003 The Society for Investigative Dermatology, Inc Terms and Conditions