Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia

Slides:

Advertisements

Similar presentations

Impact of moving target on measurement accuracy in 3D and 4D PET imaging—a phantom study Yunfeng Cui, PhD, James Bowsher, PhD, Jing Cai, PhD, Fang-Fang.

Advertisements

Evaluation of 18F-FDG PET-CT for Differentiation of Pulmonary Pathology in an Approach of Outpatient Fast Track Assessment Tjeerd S. Aukema, MD, Renato.

Lipid abnormalities in foreign-born and US-born patients in a medical group Jawali Jaranilla, MD, MPH, Terese DeFor, MS, Gabriela Vazquez Benitez, PhD,

Clinical Value of Fluorodeoxyglucose-Positron Emission Tomography/Computed Tomography in Differentiation of Malignant Mesothelioma from Asbestos-Related.

The UK Paediatric Familial Hypercholesterolaemia Register: Statin-related safety and 1- year growth data Steve E. Humphries, PhD, FRCP, Jackie Cooper,

Multimodal Imaging in the Diagnosis of Large Vessel Vasculitis: A Pictorial Review U. Salati, MBChB, MRCP(UK), Ceara Walsh, MBChB, MRCPI, Darragh Halpenny,

Jenny Dave, MS, Mark A. Ahlman, MD, Benjamin N. Lockshin, MD, David A

Gingival Metastasis as First Sign of Multiorgan Dissemination of Epithelioid Malignant Mesothelioma Andrea Billè, Marco Platania, Giuseppe Pelosi, Barbara.

Comparison of 18F-fluoro-deoxy-glucose, 18F-fluoro-methyl-choline, and 18F-DPA714 for positron-emission tomography imaging of leukocyte accumulation in.

Erythrocyte long-chain omega-3 fatty acid levels are inversely associated with mortality and with incident cardiovascular disease: The Framingham Heart.

An assessment by the Statin Liver Safety Task Force: 2014 update

Purified palmitoleic acid for the reduction of high-sensitivity C-reactive protein and serum lipids: A double-blinded, randomized, placebo controlled.

Yuji Nakamoto Clinical Lymphoma, Myeloma and Leukemia

Increased 18F-fluorodeoxyglucose uptake in abdominal aortic aneurysms in positron emission/computed tomography is associated with inflammation, aortic.

Volume 389, Issue 10071, Pages (February 2017)

Association of triglyceride-to-high density lipoprotein cholesterol ratio to cardiorespiratory fitness in men Gloria Lena Vega, PhD, Scott M. Grundy,

Emerging LDL therapies: Mipomersen—antisense oligonucleotide therapy in the management of hypercholesterolemia Peter P. Toth, MD, PhD, FAAFP, FICA, FNLA,

Diffusion-weighted magnetic resonance imaging in preoperative assessment of non– small cell lung cancer Hiroaki Nomori, MD, Yue Cong, MD, Masaru Abe,

Apolipoprotein E-containing high-density lipoprotein (HDL) modifies the impact of cholesterol-overloaded HDL on incident coronary heart disease risk:

Predictors of first-year statin medication discontinuation: A cohort study Heli Halava, MD, Risto Huupponen, MD, PhD, Jaana Pentti, BSc, Mika Kivimäki,

Prospective evaluation of postimplantation syndrome evolution on patient outcomes after endovascular aneurysm repair for abdominal aortic aneurysm Eleni.

Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Interpretation Criteria for Assessment of Antibiotic Treatment Response in Pyogenic.

Diagnosis of renal and hepatic cyst infections by 18-F-fluorodeoxyglucose positron emission tomography in autosomal dominant polycystic kidney disease

The UK Paediatric Familial Hypercholesterolaemia Register: Statin-related safety and 1- year growth data Steve E. Humphries, PhD, FRCP, Jackie Cooper,

Carmel G. Cronin, Michael Moore, Michael A. Blake

A 3-year study of atorvastatin in children and adolescents with heterozygous familial hypercholesterolemia Gisle Langslet, MD, Andrei Breazna, PhD, Euridiki.

Meredith Kilgore, PhD, Paul Muntner, PhD, J

Detection of aortic graft infection by 18-fluorodeoxyglucose positron emission tomography combined with computed tomography Gustaf Tegler, MD, Jens Sörensen,

Unexpected Small Bowel Intussusception Caused by Lung Cancer Metastasis on 18F- Fluorodeoxyglucose PET-CT Jeong Won Lee, MD, Seok-Ki Kim, MD, Ji Won Park,

Femoropopliteal prosthetic bypass graft infection due to Mycobacterium abscessus localized by FDG-PET/CT scan Michael D. Marion, MD, Mark K. Swanson,

Are We Missing Diagnosis of Large Vessel Vasculitis

C-reactive protein (CRP) elevation in patients with abdominal aortic aneurysm is independent of the most important CRP genetic polymorphism Stephen A.

An assessment by the Statin Intolerance Panel: 2014 update

Fluorine-18 Fluorodeoxyglucose Positron Emission Tomography Hypermetabolism of Vertebral Arteries Revealing Giant Cell Arteritis Aurélie Daumas, MD,

Higher triglyceride level predicts hyperuricemia: A prospective study of 6-year follow-up Yuan Zhang, Fengjiang Wei, PhD, Chen Chen, MD, Chunyou Cai,

Alirocumab dosing patterns during 40 months of open-label treatment in patients with heterozygous familial hypercholesterolemia G. Kees Hovingh, MD,

Vertebral Collapse Caused by Bone Metastasis

Targeting Lewis Y (Ley) in Small Cell Lung Cancer with a Humanized Monoclonal Antibody, hu3S193: A Pilot Trial Testing Two Dose Levels Lee M. Krug, MD,

Incidental finding of malignancy in patients preoperatively evaluated for aneurysm wall pathology using PET/CT Maarten Truijers, MD, Jillis A. Pol, MD,

Late conversion after endovascular abdominal aortic aneurysm repair in a patient with Ehlers-Danlos syndrome Georgios Karaolanis, MD, MSc, PhD, Özgun.

Massive retroperitoneal aortoiliac aneurysm rupture revealing chronic Q fever Lin-Pierre Zhao, MD, Quentin Pellenc, MD, Nicoletta Pasi, MD, Khadija Benali,

Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Interpretation Criteria for Assessment of Antibiotic Treatment Response in Pyogenic.

Yasuo Miura, MD, PhD, Mitsuru Tsudo, MD, PhD Mayo Clinic Proceedings

Mipomersen preferentially reduces small low-density lipoprotein particle number in patients with hypercholesterolemia Raul D. Santos, Frederick J. Raal,

Familial hypercholesterolemia in a European Mediterranean population—Prevalence and clinical data from 2.5 million primary care patients Alberto Zamora,

PET/CT Findings for Bone Marrow Carcinosis Because of Lung Adenocarcinoma Keisuke Watanabe, MD, Masaharu Shinkai, MD, PhD, Kenjiro Nagai, MD, Nobuhiro.

Positron Emission Tomography 18F-Fluorodeoxyglucose Uptake and Prognosis in Patients with Surgically Treated, Stage I Non-small Cell Lung Cancer: A Systematic.

Pulmonary Metastases from Cervical Adenocarcinoma Regress to a ‘Hole’ Lot of Nothing Michael Guandalini, MBBS (Hons), BPhty, Karin Steinke, MD, MS, PD,

Acute intramural hematoma of the aorta as a cause of positive fluorodeoxyglucose positron emission tomography/computed tomography Alex Ryan, MD, Barry.

A Case of Nontuberculous Mycobacteria Highly Suspected as Lung Cancer Invading the Aortic Arch Tadashi Umehara, MD, Masaya Aoki, MD, PhD, Aya Harada,

Insidious: Takayasu Arteritis

Simultaneous relief of acute visceral and limb ischemia in complicated type B aortic dissection by axillobifemoral bypass Kyung Hwa Kim, MD, PhD, Jong.

Diabetes is associated with an increased risk of cardiovascular disease in patients with familial hypercholesterolemia Martine Paquette, MSc, Sophie.

Stan P. Janssen, MD, Emile H. Comans, MD, Alexandre E

Pulmonary Atelectasis after Stereotactic Ablative Radiotherapy for a Central Lung Tumor Sashendra Senthi, MBChB, FRANZCR, Eric F Ullmann, MD, Suresh.

Efficacy and safety of lipoprotein apheresis in children with homozygous familial hypercholesterolemia: A systematic review Ilse K. Luirink, MD, Jim.

Ustekinumab treatment is associated with decreased systemic and vascular inflammation in patients with moderate-to-severe psoriasis: Feasibility study.

Marianna Koczywas, MD, Mihaela C. Cristea, MD

Nicole M. Bhave et al. JIMG 2018;11:

Don't Forget the Thyroid: Graves' Disease

Can Low-Radiation Coronary Computed Tomography Angiography Improve Upon Clinical Risk Assessment in Patients with Familial Hypercholesterolemia?* Anna.

EBUS-TBNA for the Clarification of PET Positive Intra-Thoracic Lymph Nodes—an International Multi-Centre Experience Robert C. Rintoul, FRCP, PhD, Kurt.

Inflammation in the walls of asymptomatic abdominal aortic aneurysms is not associated with increased metabolic activity detectable by 18-fluorodeoxglucose.

Endovascular repair of thoracic aortic injury after spinal instrumentation Paul Claiborne, MD, Alexandros Mallios, MD, Kevin Taubman, MD, John Blebea,

Endovascular repair of thoracic aortic injury after spinal instrumentation Paul Claiborne, MD, Alexandros Mallios, MD, Kevin Taubman, MD, John Blebea,

Late conversion after endovascular abdominal aortic aneurysm repair in a patient with Ehlers-Danlos syndrome Georgios Karaolanis, MD, MSc, PhD, Özgun.

Prosthetic Valve Endocarditis Diagnosed by 18F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography Shigeo Godo, MD, PhD, Shigeki Kushimoto,

Long-term clinical results of microsomal triglyceride transfer protein inhibitor use in a patient with homozygous familial hypercholesterolemia Anna.

Super Scan Using Positron Emission Tomography in Lung Cancer Patients

Fibrinogen and high-sensitive C-reactive protein as serologic predictors for perioperative cerebral microembolic lesions after carotid endarterectomy

Presentation transcript:

Vascular inflammation and metabolic activity in hematopoietic organs and liver in familial combined hyperlipidemia and heterozygous familial hypercholesterolemia Konstantinos Toutouzas, MD, John Skoumas, MD, Iosif Koutagiar, MD, Georgios Benetos, MD, Nikoletta Pianou, PhD, Alexandros Georgakopoulos, MD, Spyros Galanakos, MD, Alexios Antonopoulos, MD, Maria Drakopoulou, MD, Evangelos K. Oikonomou, MD, Pavlos Kafouris, PhD, Emmanouil Athanasiadis, PhD, Marinos Metaxas, PhD, George Spyrou, PhD, Zoi Pallantza, MD, Nikolaos Galiatsatos, MD, Constantina Aggeli, MD, Charalampos Antoniades, MD, Georgia Keramida, MD, Adrien M. Peters, MD, Constantinos D. Anagnostopoulos, MD, Dimitris Tousoulis, MD Journal of Clinical Lipidology Volume 12, Issue 1, Pages 33-43 (January 2018) DOI: 10.1016/j.jacl.2017.10.019 Copyright © 2017 National Lipid Association Terms and Conditions

Figure 1 Flow chart of the study. Journal of Clinical Lipidology 2018 12, 33-43DOI: (10.1016/j.jacl.2017.10.019) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 2 Comparison of inflammatory biomarkers levels in patients with familial combined hyperlipidemia (FCH), heterozygous familial hypercholesterolemia (heFH), and nondyslipidemics controls. Individuals with FCH exhibited higher high-sensitivity C-reactive protein (hs-CRP) (A) and fibrinogen (B) values in comparison with heFH and controls. The bottom of the boxes represents the first quartile, the top of the boxes represents the third quartile, and the line in the boxes represents the median value. Journal of Clinical Lipidology 2018 12, 33-43DOI: (10.1016/j.jacl.2017.10.019) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 3 Fluorodeoxyglucose signal quantified as target-to-background ratio (TBR) within the wall of the thoracic aorta (A), abdominal aorta (B), and whole aorta (C), is greater in patients with familial combined hyperlipidemia (FCH) compared with individuals with heterozygous familial hypercholesterolemia (heFH) and nondyslipidemic controls. The bottom of the boxes represents the first quartile, the top of the boxes represents the third quartile, and the line in the boxes represents the median value. Journal of Clinical Lipidology 2018 12, 33-43DOI: (10.1016/j.jacl.2017.10.019) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 4 Fluorodeoxyglucose uptake within the liver (A), the spleen (B), and the bone marrow (C) of subjects with familial dyslipidemias and of nondyslipidemic individuals. The bottom of the boxes represents the first quartile, the top of the boxes represents the third quartile, and the line in the boxes represents the median value. Journal of Clinical Lipidology 2018 12, 33-43DOI: (10.1016/j.jacl.2017.10.019) Copyright © 2017 National Lipid Association Terms and Conditions

Figure 5 Increased hepatic, spleen, aortic, and bone marrow fluorodeoxyglucose (FDG) uptake in patients with familial combined hyperlipidemia (FCH). Fused 18 fluorodeoxyglucose positron-emission tomography (18F-FDG PET/CT) axial views of liver (green crosses) and spleen (marked as white ∗) (A1, B1, C1), coronal views of aorta (blue arrows) (A2, B2, C2), and sagittal views of bone marrow (red arrows) (A3, B3, C3). There was an intense FDG uptake quantified as target-to-background ratio (TBR) within liver, spleen, aortic wall, and bone marrow in patients with FCH (A1–3) compared with subjects with heFH (B1–3) and controls (C1–3). Journal of Clinical Lipidology 2018 12, 33-43DOI: (10.1016/j.jacl.2017.10.019) Copyright © 2017 National Lipid Association Terms and Conditions