Preclinical investigation of the development of osteoarthritis-like degeneration in a rat trauma model using micro-computed tomography T.H. Steiner,

Slides:

Advertisements

Similar presentations

Micro-CT bone structure evaluation in the Pond-Nuki dog model

Advertisements

X. I. Gu, P. E. Palacio-Mancheno, D. J. Leong, Y. A. Borisov, E

Validity and responsiveness of a new measure of knee osteophytes for osteoarthritis studies: data from the osteoarthritis initiative M. Hakky, M. Jarraya,

Full-thickness cartilage defects repaired by human induced pluripotent stem cells (IPSCS)-derived mesenchymal stem cells and plga scaffolds D. Shi, X.

Changes in the T2 relaxation value of the tibiofemoral articular cartilage about 6 months after anterior cruciate ligament reconstruction using the double-bundle.

Cartilage Thickness, Denudation and Kl Grade: A Study of Medial Femorotibial Joints in 8,890 Knees from the Osteoarthritis Initiative G. Guillard, G.R.

T1ρ and T2 relaxation times predict progression of knee osteoarthritis

P.B. Chan, W. Yang, C. Wen, C. Yan, K. Chiu

3D Knee Bone Shape Predisposes to ACL Rupture: Data from the Osteoarthritis Initiative and the Kanon Study M.A. Bowes, S. Lohmander, P.G. Conaghan, R.

R. Takeuchi, H. Ishikawa, T. Kuniya, A. Nakazawa

S. Gavard Osteoarthritis and Cartilage

Isotropic three-dimensional T2 mapping of knee cartilage with T2-prepared segmented gradient ECHO at 3T R. Colotti, P. Omoumi, R.B. van Heeswijk Osteoarthritis.

Prospective economic evaluation of the costs for medications and nutraceuticals in knee osteoarthritis M. Chung, N. Zhao, J.B. Wong, C. Wang Osteoarthritis.

Bone shape does not cause OA – But OA does change bone shape; a study on data from 4654 knees from the Osteoarthritis Initiative M.A. Bowes, C.B. Wolstenholme,

Does a yoga-strengthening program for women with knee osteoarthritis have an effect on gait patterns? An investigation with principal components analysis

Advances in visualization of knee cartilage and meniscal morphology with standing computed tomography N.A. Segal, A. Guermazi Osteoarthritis and Cartilage

Mechanical load-induced bone remodeling requires FSTL3 expression

Sensitivity to Change of 3D Meniscal Measures in Rapidly Progressing Knee Osteoarthritis and Association With Radiographic Joint Space Width Loss M.

Quantitatively-measured bone marrow lesions in the patellofemoral joint: distribution and association with pain C. Ratzlaff, R. Russell, J. Duryea Osteoarthritis.

Automatic cartilage segmentation and measurement for diagnosis of OA using 3D box and Gaussian filters X. Cui, S. Li, M. Yu, H. Kim, K.-S. Kwack, B.-H.

Mineralization of meniscal enthesis in osteoarthritic knees

Spontaneous osteoarthritis in Str/ort mice is unlikely due to greater vulnerability to mechanical trauma B. Poulet, T.A.T. Westerhof, R.W. Hamilton,

G. Venne, S. Pang, Y. Tse, R. Ellis Osteoarthritis and Cartilage

Comparison of the Usefulness of Laser-induced Photoacoustic Measurement & Magnetic Resonance Imaging (T2 Mapping, Diffusion Tensor Imaging) for Assessing.

Replicability of recommended exercise interventions for knee osteoarthritis: a descriptive systematic review of current clinical guidelines and recommendations

Maintaining sufficient serum vitamin d levels over two years is associated with improved knee structural and symptomatic outcomes in people with knee.

Dietary fatty acids differentially affect the development of injury-induced osteoarthritis with diet-induced obesity in mice C.-L. Wu, D. Jain, D. Little,

X. Cui, S. Li, H. Kim, J.-Y. Chung, K.-S. Kwack, B.-H. Min

P. Yuan, X. Zhang, W. Yang, W. Kang, B. Yang, J. li, B. Chen, X. Li, B

P. -H. Tsai, M. -C. Chou, H. -S. Lee, C. -H. Lee, H. -W. Chung, Y. -C

Y. Sun, N. Haines, A. Roberts, M. Ruffolo, D. Mauerhan, J. Ingram, M

T1rho and T2 Relaxation of Knee Articular Cartilage in Patients With and at Risk for Knee Osteoarthritis: A Systematic Review and Meta-Analysis H.F.

The effects of body weight unloading on hip and knee biomechanical parameters during overground walking A.G. Fischer, A. Wolf Osteoarthritis and Cartilage

Investigating the role of bone microarchitecture in early osteoarthritis using new in vivo 3D high-resolution peripheral quantitative computed tomography

Multimodal imaging demonstrates concomitant changes in bone and cartilage after destabilisation of the medial meniscus and increased joint laxity J.P.

Mice with global deletion of mitogen inducible gene 6 display rapid and severe cartilage and subchondral bone damage after ligament and meniscus injury

Loss of Frzb and Sfrp1 differentially affects joint homeostasis in instability-induced osteoarthritis S. Thysen, F.P. Luyten, R.J. Lories Osteoarthritis.

K.S. Vanderman, R. Loeser, S. Chubinskaya, C.M. Ferguson

Contrast-enhanced computed tomography imaging using a cationic contrast agent correlates with the equilibrium modulus of mouse tibial plateau cartilage

M.N. Khan, M.Y. Ansari, T.M. Haqqi Osteoarthritis and Cartilage

C. -H. Chou, H. -G. Wisniewski, P. Band, J. Huebner, T. Stabler, C

Knee biomechanical and quantitative magnetic resonance imaging variables three months after anterior cruciate ligament reconstruction A. Khandha, J.J.

M.L. Roemhildt, A.E. Gauthier Osteoarthritis and Cartilage

B. C. Roberts, D. Thewlis, L. B. Solomon, G. Mercer, K. J. Reynolds, E

M. F. Pustjens, S. C. Mastbergen, W. H. Noort-Van der Laan, R. J

Effects of low level laser therapy: a study of status of cartilage, subchondral bone and gait adaptation in the rat anterior cruciate ligament transection.

Medial meniscus posterior horn zones show differing responses to static loading in subjects with knee osteoarthritis compared to controls N.E. Calixto,

Z. Huang, T. Stabler, F. Pei, V. Kraus Osteoarthritis and Cartilage

Correlation between 18F-FDG and F-18 sodium fluoride (NaF) PET/MRI and gross morphology of the knee in a canine model of osteoarthritis. M.I. Menendez,

Quantitative pre-clinical screening of therapeutics for joint diseases using contrast enhanced micro-computed tomography N.J. Willett, T. Thote, M. Hart,

Damps provide a link between joint tissue damage and pain through direct activation of TLR4 expressed by sensory neurons R.E. Miller, P.B. Tran, S. Ishihara,

G. Ren, P. Railton, J. L. Whittaker, C. Leonard, P. T. Salo, J

Evidence for bone mineral density and bone resorption in middle and elderly women with knee osteoarthritis in Shanghai: a cross sectional study Q. Xiaofeng

Walking with increased foot progression angle can reduce joint compression in individuals with knee OA K. Manal, T.S. Buchanan Osteoarthritis and Cartilage

Monocyte chemoattractant protein 1 induced chondrocytes degeneration and cartilage degradation in osteoarthritis X. yuankun, K. Yan, W. Bin, L. Jian-Hao

Individuals with severe knee OA are at increased risk of all-cause and cardiovascular disease-specific mortality: The johnston county osteoarthritis project

P. Rahnamay Moshtagh, N. M. Korthagen, S. G. Plomp, B. Pouran, A

Multivariate pattern analysis of physical activity and cartilage health: data from the osteoarthritis initiative E. Halilaj, T.J. Hastie, G.E. Gold,

Sensitive discrimination metrics of structural deterioration in a preclinical osteoarthritis- like rat trauma model A. Villarreal, K. Atal, T.H. Steiner,

Leptin signaling and body weight are independent mediators of spontaneous knee osteoarthritis in female rats J. Hudson, M. West, Y. Fu, T. Griffin Osteoarthritis.

Imaging biomarker with T1 and T2 mappings in osteoarthritis – In vivo human articular cartilage study C. Yan, C. Wong, T. Li, N. Gong, Q. Chan, K. Chiu

Coronal tibial slope is associated with incident accelerated knee osteoarthritis: data from the Osteoarthritis Initiative J.B. Driban, A.C. Stout, J.

D.J. Pawson, M. Glanzmann, H. Bangar, K. Atal, R. Müller, K.S. Stok

Knee kinematic and kinetic modifications under body weight unloading during overground walking at a constant speed A.G. Fischer, E.M. Debbi, A. Wolf

Discovery of a small molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying treatment for knee osteoarthritis J.D. Hood, V.

E. M. Debbi, B. Bernfeld, E. Gray, M. Salai, Y. Levy, A. Gold, R

Comprehensive morphological characterisation of osteoarthritis in a preclinical rabbit trauma model using micro computed tomography K.S. Stok, K. Atal,

A. Carlson, B. Bothner, R. June Osteoarthritis and Cartilage

General Information Osteoarthritis and Cartilage

Long-term effects of vitamin d supplementation and maintaining vitamin d sufficiency on knee osteoarthritis over 5 years B. Antony, S. Zheng, J. Burgess,

Presentation transcript:

Preclinical investigation of the development of osteoarthritis-like degeneration in a rat trauma model using micro-computed tomography T.H. Steiner, R.J. Choo, A. Quintin, M. Wilke, D. Nesic, M. Zulliger, R. Müller, K.S. Stok Osteoarthritis and Cartilage Volume 20, Pages S50-S51 (April 2012) DOI: 10.1016/j.joca.2012.02.599 Copyright © 2012 Terms and Conditions

Figure 1 Sagittal cut through a knee joint with microCT and contrast agent. F: femur, T: tibia, CA: contrast agent, M: meniscus, Cg: cartilage. Osteoarthritis and Cartilage 2012 20, S50-S51DOI: (10.1016/j.joca.2012.02.599) Copyright © 2012 Terms and Conditions

Figure 2 (a) 2D Cg.Th of histology and microCT slice for healthy and OA-induced rat knees (p < 0.001). (b-c) 3D thickness maps of tibial cartilage for the two models. Osteoarthritis and Cartilage 2012 20, S50-S51DOI: (10.1016/j.joca.2012.02.599) Copyright © 2012 Terms and Conditions

Figure 3 OA-induced tibio-femoral rat joint in coronal plane with bone (white) and cartilage (colour indicates thickness) allowing direct investigation of local bone adaptation with cartilage changes. Osteoarthritis and Cartilage 2012 20, S50-S51DOI: (10.1016/j.joca.2012.02.599) Copyright © 2012 Terms and Conditions