Angus Hughes, Susan Ballard, Sheena Sullivan, Caroline Marshall 

Slides:



Advertisements
Similar presentations
SURVEILLANCE FOR GLYCOPEPTIDE-RESISTANT ENTEROCOCCI Drs N Bosman, T Nana & C Sriruttan CMID NHLS Dr Charlotte Sriruttan SASCM 3/11.
Advertisements

MRSA and VRE. MRSA  1974 – MRSA accounted for only ____of total staph infections  1995 – MRSA accounted for _____ of total staph infections  2004 –
RESULTS INTRODUCTION METHODS CONCLUSION  Since the early 90’s Enterococcus faecium resistant to Glycopeptides (GRE) have emerged in several French hospitals.
Nosocomial Antibiotic Resistant Organisms
Table 4 Risk factors for acquisition of vancomycin-resistant enterococcal (VRE) colonization after transplantation for 120 liver transplant recipients.
Angelo Berchieri Jr  Clinical Microbiology and Infection 
Antimicrobial activity of a UV-stable bacteriocin-like inhibitory substance (BLIS) produced by Enterococcus faecium strain DSH20 against vancomycin-resistant.
Screening for vancomycin-resistant enterococci (VRE) Why bother?
Aortic Root Replacement in a Patient With Vancomycin-Resistant Enterococcus faecium Endocarditis and Leukemia  Igor E. Konstantinov, MD, Kenton J. Zehr,
NOSOCOMIAL ANTIBIOTIC RESISTANT ORGANISMS
Journal of Microbiology, Immunology and Infection
Use of a daily disinfectant cleaner instead of a daily cleaner reduced hospital-acquired infection rates  Michelle J. Alfa, PhD, Evelyn Lo, MD, Nancy.
REDUCED RATES OF VANCOMYCIN RESISTANT ENTEROCOCCI (VRE) COLONIZATION
Medical Microbiology Chapter 24 Enterococcus.
An outbreak of hospital-acquired Pseudomonas aeruginosa infection caused by contaminated bottled water in intensive care units  T. Eckmanns, M. Oppert,
Management of multidrug-resistant enterococcal infections
To screen or not to screen for VRE in immunocompromised patients?
Interventions to reduce colonisation and transmission of antimicrobial-resistant bacteria in intensive care units: an interrupted time series study and.
G. L. Daikos, P. Triantafyllopoulou, V. Syriopoulou, D
Colonization by vancomycin-resistant enterococci of the intestinal tract of patients in intensive care units from French general hospitals  Armelle Boisivon,
Molecular epidemiology of a clonal outbreak of multidrug-resistant Acinetobacter baumannii in a university hospital in Italy  R. Zarrilli, R. Casillo,
Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium  J. Top, R. Willems, H. Blok, M. de Regt, K.
Brett G. Mitchell, Anthony Williams, Zorana Wong, Jayne O'Connor 
Ecological replacement of Enterococcus faecalis by multiresistant clonal complex 17 Enterococcus faecium  J. Top, R. Willems, H. Blok, M. de Regt, K.
Genome-based insights into the evolution of enterococci
High prevalence of ST-78 infection-associated vancomycin-resistant Enterococcus faecium from hospitals in Asunción, Paraguay  M.A. Khan, J.B. Northwood,
Angelo Berchieri Jr  Clinical Microbiology and Infection 
Genotypic characterisation of vancomycin-resistant Enterococcus faecium isolates from haemato-oncological patients at Olomouc University Hospital, Czech.
Diana Khuu, Mark L. Eberhard, Benjamin N
Quantifying the relative effect of environmental contamination on surgical ward MRSA incidence: An exploratory analysis  Xing J. Lee, Anthony N. Pettitt,
Wastewater drainage system as an occult reservoir in a protracted clonal outbreak due to metallo-β-lactamase-producing Klebsiella oxytoca  S. Vergara-López,
Emergence of vancomycin-resistant enterococci in a tertiary hospital in Crete, Greece: a cluster of cases and prevalence study on intestinal colonisation 
Outbreak of vancomycin-resistant Enterococcus spp
Strategies for managing today's infections
Control of infections due to extended-spectrum β-lactamase-producing organisms in hospitals and the community  R.E. Warren, G. Harvey, R. Carr, D. Ward,
How much do superbugs cost Australian hospitals
Microbiological and epidemiological studies of Enterococcus faecium resistant to amoxycillin in a university hospital in eastern France  M. Thouverez,
Decreasing rates of resistance to penicillin, but not erythromycin, in Streptococcus pneumoniae after introduction of a policy to restrict antibiotic.
G.S. Whiteley, T.O. Glasbey, P.P. Fahey  Infection, Disease & Health 
Certification in cardiothoracic surgical critical care: A distinction for some or for all?  Nicholas D. Andersen, MD  The Journal of Thoracic and Cardiovascular.
MIC distribution and inoculum effect of LY333328: a study of vancomycin-susceptible and VanA-type and VanC-type enterococci obtained from intensive care.
An outbreak of Clostridium difficile infections due to new PCR ribotype 826: epidemiologic and microbiologic analyses  M.J.T. Crobach, A.F. Voor in 't.
W. Hryniewicz, K. Szczypa, M. Bronk, A. Samet, A. Hellmann, K
Comparison of vancomycin and linezolid in patients with peripheral vascular disease and/or diabetes in an observational European study of complicated.
Outbreak of infection with high-level gentamicin-resistant Enterococcus faecalis (HLGRE) in a Norwegian hospital  Ø. Wendelbo, R. Jureen, G.E. Eide, A.
Zika virus infection: Some issues of urgent attention
Eugene M. Tan, Jasmine R. Marcelin, Abinash Virk 
Angus Hughes, Susan Ballard, Sheena Sullivan, Caroline Marshall 
Epidemiological investigation of a nosocomial outbreak of multidrug-resistant Corynebacterium striatum at one Belgian university hospital  A. Verroken,
Effect of length of stay in intensive care unit on hospital and long-term mortality of critically ill adult patients  T.A. Williams, K.M. Ho, G.J. Dobb,
Comparative bactericidal activities of daptomycin, glycopeptides, linezolid and tigecycline against blood isolates of Gram-positive bacteria in Taiwan 
The dynamic relationship between antibiotic use and the incidence of vancomycin- resistant Enterococcus: time-series modelling of 7-year surveillance data.
Thomas G. Heazlewood, Kathryn Ogden, Damhnat McCann 
Point prevalence surveys of healthcare-associated urinary tract infections: Development, pilot testing and evaluation of face-to-face and online educational.
Vancomycin resistance emerging in a clonal outbreak caused by ampicillin-resistant Enterococcus faecium  Stig Harthug, A. Digranes, O. Hope, B.E. Kristiansen,
“It's in your hands – Prevent sepsis in health care”; 5th May 2018 World Health Organization (WHO) SAVE LIVES: Clean Your Hands campaign  Hiroki Saito 
Clonality among ampicillin-resistant Enterococcus faecium isolates in Sweden and relationship with ciprofloxacin resistance  E. Torell, J. Kühn, B. Olsson-Liljeauist,
The first clinical isolate of Enterococcus faecium with the VanB phenotype in a teaching hospital in Greece  J. Papaparaskevas, J. Stefanou, A. Vatopoulos,
E. Tacconelli  Clinical Microbiology and Infection 
C. Novais, T.M. Coque, J.C. Sousa, L.V. Peixe 
Surveillance of intestinal colonization and of infection by vancomycin-resistant enterococci in hospitalized cancer patients  Florence Moulin, Sandrine.
Volume 67, Issue 6, Pages (June 2005)
“It's in your hands – Prevent sepsis in health care”; 5th May 2018 World Health Organization (WHO) SAVE LIVES: Clean Your Hands campaign  Hiroki Saito 
Susceptibility of multi-drug-resistant Pseudomonas aeruginosa in intensive care units: results from the European MYSTIC study group†   H. Goossens  Clinical.
Test results: characterising the antimicrobial activity of daptomycin
Hospital outbreak of vancomycin-resistant enterococci caused by a single clone of Enterococcus raffinosus and several clones of Enterococcus faecium 
Bactericidal activity and synergy studies of BAL9141, a novel pyrrolidinone-3- ylidenemethyl cephem, tested against streptococci, enterococci and methicillin-resistant.
Impact of Cardiothoracic Resident Turnover on Mortality After Cardiac Surgery: A Dynamic Human Factor  Jeffrey H. Shuhaiber, MD, Kimberley Goldsmith,
Angus Hughes, Susan Ballard, Sheena Sullivan, Caroline Marshall 
Effectiveness of insertion and maintenance bundles in preventing peripheral intravenous catheter-related complications and bloodstream infection in hospital.
Presentation transcript:

An outbreak of vanA vancomycin-resistant Enterococcus faecium in a hospital with endemic vanB VRE  Angus Hughes, Susan Ballard, Sheena Sullivan, Caroline Marshall  Infection, Disease & Health  DOI: 10.1016/j.idh.2018.12.002 Copyright © 2018 Terms and Conditions

Figure 1 Timeline of the outbreak: Length of stay on CTS, ICU and other hospital wards for cases and implementation of key infection control measures. CTS-pos and ICU-pos = stay on ward with any positive vanA VREfm isolate; CTS-neg and ICU-neg = stay on ward when negative for vanA VREfm or status not yet known (assumed negative); other_ward = stay on any other ward in hospital excluding ICU and CTS and regardless of vanA VREfm status. Black dots represent vanA VREfm acquisitions detected on discharge screening to other_ward or from hospital. Note. CHG = Chlorhexidine gluconate; CTS = cardiothoracic surgery; ICU = intensive care unit; VRE = vancomycin-resistant enterococci; VREfm = vancomycin-resistant Enterococcus faecium. Infection, Disease & Health DOI: (10.1016/j.idh.2018.12.002) Copyright © 2018 Terms and Conditions

Figure 2 Epidemiological curves of new vanA VREfm cases on ICU (a) and CTS ward (b) over the course of the outbreak. Timing of some key interventions applied specifically to each ward are indicated. Note. CHG = Chlorhexidine gluconate; CTS = cardiothoracic surgery; ICU = intensive care unit; VRE = vancomycin-resistant enterococci; VREfm = vancomycin-resistant Enterococcus faecium. Infection, Disease & Health DOI: (10.1016/j.idh.2018.12.002) Copyright © 2018 Terms and Conditions