Volume 146, Issue 5, Pages e1 (May 2014)

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Volume 146, Issue 5, Pages 1249-1255.e1 (May 2014) A New Laboratory-Based Algorithm to Predict Development of Hepatocellular Carcinoma in Patients With Hepatitis C and Cirrhosis Hashem B. El-Serag, Fasiha Kanwal, Jessica A. Davila, Jennifer Kramer, Peter Richardson Gastroenterology Volume 146, Issue 5, Pages 1249-1255.e1 (May 2014) DOI: 10.1053/j.gastro.2014.01.045 Copyright © 2014 AGA Institute Terms and Conditions

Figure 1 The predicted HCC probability at different AFP levels is modified by ALT levels. Results of bivariate analysis. Gastroenterology 2014 146, 1249-1255.e1DOI: (10.1053/j.gastro.2014.01.045) Copyright © 2014 AGA Institute Terms and Conditions

Figure 2 The positive and negative predictive values at different probability cutoffs resulting from a model containing AFP, age, ALT, platelets, and their interaction terms. Gastroenterology 2014 146, 1249-1255.e1DOI: (10.1053/j.gastro.2014.01.045) Copyright © 2014 AGA Institute Terms and Conditions

Figure 3 Contour plot showing HCC probability at AFP level of 20 ng/mL as calculated from a predictive model containing AFP, age, ALT, and platelets. HCC probability at age 50 years (fixed) varies considerably over a range of ALT and platelets values. HCC probabilities are depicted in different colors. Gastroenterology 2014 146, 1249-1255.e1DOI: (10.1053/j.gastro.2014.01.045) Copyright © 2014 AGA Institute Terms and Conditions

Figure 4 Contour plot showing HCC probability at AFP level of 20 ng/mL as calculated from a predictive model containing AFP, age, ALT, and platelets. HCC probability at age 70 years varies considerably over a range of ALT and platelets values. HCC probabilities are depicted in different colors. Gastroenterology 2014 146, 1249-1255.e1DOI: (10.1053/j.gastro.2014.01.045) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 1 (A) Predicted HCC probability modified by alkaline phosphatase. (B) Predicted HCC probability modified by bilirubin. Gastroenterology 2014 146, 1249-1255.e1DOI: (10.1053/j.gastro.2014.01.045) Copyright © 2014 AGA Institute Terms and Conditions

Supplementary Figure 2 The positive and negative predictive values at different probability cutoffs resulting from a model containing AFP, age, ALT, platelets, and their interaction terms. Gastroenterology 2014 146, 1249-1255.e1DOI: (10.1053/j.gastro.2014.01.045) Copyright © 2014 AGA Institute Terms and Conditions