Osteoarthritis year in review 2017: biology C.T. Appleton  Osteoarthritis and Cartilage  Volume 26, Issue 3, Pages 296-303 (March 2018) DOI: 10.1016/j.joca.2017.10.008 Copyright © 2017 Terms and Conditions

Fig. 1 Topic areas encompassed by studies published on biological mechanisms of OA between 2016 and 2017. Topics are organized in proposed pillars across a continuum of OA biology. The figure is not meant to be complete, but represents topics that were featured or commonly reported in the literature based on the year in review. Osteoarthritis and Cartilage 2018 26, 296-303DOI: (10.1016/j.joca.2017.10.008) Copyright © 2017 Terms and Conditions

Fig. 2 Schematic summary of conclusions from mechanistic studies of OA biology between 2016 and 2017. Themes are shown in relation to the most significantly associated primary cause (risk factor) for OA based on the context of studies included. Primary causes include injury and altered biomechanics, ageing, and systemic metabolic derangement (e.g., hypercholesterolemia). Green indicators represent a positive effect (protective against OA). Red indicators represent a negative effect (promoting OA). Arrows indicate a positive relationship (stimulatory effect), whereas blunt-ended arrows indicate an inhibitory effect. Based on reported evidence from the 2016–2017 literature. Osteoarthritis and Cartilage 2018 26, 296-303DOI: (10.1016/j.joca.2017.10.008) Copyright © 2017 Terms and Conditions