Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in.

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Presentation transcript:

Autologous mitochondrial transfer as a complementary technique to intracytoplasmic sperm injection to improve embryo quality in patients undergoing in vitro fertilization—a randomized pilot study Elena Labarta, M.D., Ph.D., Maria José de los Santos, Ph.D., Sonia Herraiz, Ph.D., Maria José Escribá, Ph.D., Alicia Marzal, M.D., Anna Buigues, B.Sc., Antonio Pellicer, M.D. Fertility and Sterility Volume 111, Issue 1, Pages 86-96 (January 2019) DOI: 10.1016/j.fertnstert.2018.09.023 Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Schematic drawing representing the complete procedure. (B) Study flow diagram. Oocytes from the same patient were randomized to receive either conventional ICSI or AUGMENT. Comparisons were made between embryos coming from both groups. AUGMENT = autologous mitochondrial transfer; ET = embryo transfer; MII = metaphase II; ICSI = intracytoplasmic sperm injection; mtDNA = mitochondrial DNA; PGT-A = preimplantation genetic testing for aneuploidy. Fertility and Sterility 2019 111, 86-96DOI: (10.1016/j.fertnstert.2018.09.023) Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

Figure 1 (A) Schematic drawing representing the complete procedure. (B) Study flow diagram. Oocytes from the same patient were randomized to receive either conventional ICSI or AUGMENT. Comparisons were made between embryos coming from both groups. AUGMENT = autologous mitochondrial transfer; ET = embryo transfer; MII = metaphase II; ICSI = intracytoplasmic sperm injection; mtDNA = mitochondrial DNA; PGT-A = preimplantation genetic testing for aneuploidy. Fertility and Sterility 2019 111, 86-96DOI: (10.1016/j.fertnstert.2018.09.023) Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions

Figure 2 (A) Day 5 blastocyst formation rate per zygote obtained in Control and AUGMENT groups. (B) ASEBIR score of embryos on day 5 of development. ASEBIR = Association for the Study of Reproductive Biology; other abbreviations as in Figure 1. Fertility and Sterility 2019 111, 86-96DOI: (10.1016/j.fertnstert.2018.09.023) Copyright © 2018 American Society for Reproductive Medicine Terms and Conditions