Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline Alan Penzias, M.D., Kristin Bendikson,

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Presentation transcript:

Role of metformin for ovulation induction in infertile patients with polycystic ovary syndrome (PCOS): a guideline Alan Penzias, M.D., Kristin Bendikson, M.D., Samantha Butts, M.D., M.S.C.E., Christos Coutifaris, M.D., Ph.D., Tommaso Falcone, M.D., Gregory Fossum, M.D., Susan Gitlin, Ph.D., Clarisa Gracia, M.D., M.S.C.E., Karl Hansen, M.D., Ph.D., Andrew La Barbera, Ph.D., Jennifer Mersereau, M.D., Randall Odem, M.D., Richard Paulson, M.D., Samantha Pfeifer, M.D., Margareta Pisarska, M.D., Robert Rebar, M.D., Richard Reindollar, M.D., Mitchell Rosen, M.D., Jay Sandlow, M.D., Michael Vernon, Ph.D. Alan Penzias, M.D., Kristin Bendikson, M.D., Samantha Butts, M.D., M.S.C.E., Christos Coutifaris, M.D., Ph.D., Tommaso Falcone, M.D., Gregory Fossum, M.D., Susan Gitlin, Ph.D., Clarisa Gracia, M.D., M.S.C.E., Karl Hansen, M.D., Ph.D., Andrew La Barbera, Ph.D., Jennifer Mersereau, M.D., Randall Odem, M.D., Richard Paulson, M.D., Samantha Pfeifer, M.D., Margareta Pisarska, M.D., Robert Rebar, M.D., Richard Reindollar, M.D., Mitchell Rosen, M.D., Jay Sandlow, M.D., Michael Vernon, Ph.D. Fertility and Sterility Volume 108, Issue 3, Pages 426-441 (September 2017) DOI: 10.1016/j.fertnstert.2017.06.026 Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 1 Comparison of live-birth rates with clomiphene citrate versus metformin with clomiphene citrate (28). (Reprinted by permission of John Wiley & Sons, Inc. The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.) Fertility and Sterility 2017 108, 426-441DOI: (10.1016/j.fertnstert.2017.06.026) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Clinical pregnancy rates and live-birth rates with various therapies in clomiphene citrate–resistant women (45). (Reprinted by permission of Oxford University Press. Moll 2007 Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.) Fertility and Sterility 2017 108, 426-441DOI: (10.1016/j.fertnstert.2017.06.026) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 2 Clinical pregnancy rates and live-birth rates with various therapies in clomiphene citrate–resistant women (45). (Reprinted by permission of Oxford University Press. Moll 2007 Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.) Fertility and Sterility 2017 108, 426-441DOI: (10.1016/j.fertnstert.2017.06.026) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions

Figure 3 (A) Pregnancy and (B) live-birth rates in lean women with polycystic ovary syndrome treated with metformin vs clomiphene citrate (75). (Reprinted by permission of Oxford University Press. Misso 2012 Oxford University Press on behalf of the European Society of Human Reproduction and Embryology.) Fertility and Sterility 2017 108, 426-441DOI: (10.1016/j.fertnstert.2017.06.026) Copyright © 2017 American Society for Reproductive Medicine Terms and Conditions