Evidence for at Least Two Major Loci Influencing Human Fatness

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Evidence for at Least Two Major Loci Influencing Human Fatness Ingrid B. Borecki, John Blangero, Treva Rice, Louis Pérusse, Claude Bouchard, D.C. Rao The American Journal of Human Genetics Volume 63, Issue 3, Pages 831-838 (September 1998) DOI: 10.1086/302006 Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 1 Bivariate segregation model, including unmeasured etiologic factors (represented by circles). g = a major locus, G = a multifactorial/polygenic component, and E = a nontransmitted environmental residual. Each of these factors potentially affect the measured phenotypes (represented by squares). Trait 1 is BMI, and trait 2 is FM. Single-headed arrows indicate the assumed direction of causation, and double-headed arrows indicate correlation. The American Journal of Human Genetics 1998 63, 831-838DOI: (10.1086/302006) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 2 Main hypotheses under the bivariate model The American Journal of Human Genetics 1998 63, 831-838DOI: (10.1086/302006) Copyright © 1998 The American Society of Human Genetics Terms and Conditions

Figure 3 Bivariate segregation analysis of BMI (trait 1) and FM (trait 2) The American Journal of Human Genetics 1998 63, 831-838DOI: (10.1086/302006) Copyright © 1998 The American Society of Human Genetics Terms and Conditions