Madhav Swaminathan, MD, Christopher C. C. Hudson, FRCPC, Barbara G

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Impact of Early Renal Recovery on Survival After Cardiac Surgery-Associated Acute Kidney Injury Madhav Swaminathan, MD, Christopher C.C. Hudson, FRCPC, Barbara G. Phillips-Bute, PhD, Uptal D. Patel, MD, Joseph P. Mathew, MD, Mark F. Newman, MD, Carmelo A. Milano, MD, Andrew D. Shaw, MB, FRCA, Mark Stafford-Smith, MD, FRCPC The Annals of Thoracic Surgery Volume 89, Issue 4, Pages 1098-1104 (April 2010) DOI: 10.1016/j.athoracsur.2009.12.018 Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 1 Frequency distribution is shown of early renal recovery, defined as the percentage decrease in creatinine 24 hours after its peak value (PD24) in the (A) entire study population, and in the subsets of patients grouped according to severity of acute kidney injury (AKI) based on standard criteria of (B) stage I, (C) stage II, and (D) stage III. The Annals of Thoracic Surgery 2010 89, 1098-1104DOI: (10.1016/j.athoracsur.2009.12.018) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 2 Separate survival curves are shown for long-term survival according to early renal recovery, as defined by the percentage decrease in creatinine 24 hours after its peak value (PD24) of 9% (black line), 18% (dashed gray line), and 26% (solid gray line), representing the 25th, 50th, and 75th percentiles, respectively. The Annals of Thoracic Surgery 2010 89, 1098-1104DOI: (10.1016/j.athoracsur.2009.12.018) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions

Fig 3 The effect of early renal recovery on the mortality risk is shown by inserting hypothetical values for preoperative creatinine (1.0 mg/dL),with peak postoperative creatinine levels of 1.5, 2.0, and 3.0 mg/dL as examples of acute kidney injury (AKI) stages I (diamonds), II (squares), and III (triangles), respectively, and mean European System for Cardiac Operative Risk Evaluation (EuroSCORE) inserted into the primary model. Predicted 1-year mortality was calculated for each AKI stage based on three different values (10%, 20%, and 30%) of PD24, defined as percentage decrease in creatinine 24 hours after its peak value. The Annals of Thoracic Surgery 2010 89, 1098-1104DOI: (10.1016/j.athoracsur.2009.12.018) Copyright © 2010 The Society of Thoracic Surgeons Terms and Conditions