Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis. Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis.

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Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis. Therapeutic effects of TIP60 allosteric modification in DSS-induced colitis. Colitis was induced by adding 4% DSS to pH-balanced tap water of study mice. Disease progression was assessed by daily monitoring of body weight, stool consistency, and fecal blood. B7A (4 mg kg−1 day−1, 7 days) or DMSO control was injected intraperitoneally 1 week after DSS administration. The effects of B7A treatment on (A) body weight, (B) colon length, and (C) gut histology (hematoxylin and eosin–stained paraffin sections) are shown. (D) Frequency of FOXP3+ Treg cells in the spleen and lymph nodes of B7A-treated compared with DMSO-treated mice. n = 10 to 12 mice per group. Khalid Bin Dhuban et al. Sci. Immunol. 2017;2:eaai9297 Copyright © 2017 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works.