Smoking Cessation as a Possible Risk Factor for the Development of Aspirin- Exacerbated Respiratory Disease in Smokers Hiroaki Hayashi, MD, Yuma Fukutomi,

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Smoking Cessation as a Possible Risk Factor for the Development of Aspirin- Exacerbated Respiratory Disease in Smokers Hiroaki Hayashi, MD, Yuma Fukutomi, MD, PhD, Chihiro Mitsui, MD, Eiji Nakatani, MS, Kentaro Watai, MD, Yosuke Kamide, MD, PhD, Kiyoshi Sekiya, MD, Takahiro Tsuburai, MD, PhD, Satoru Ito, MD, PhD, Yoshinori Hasegawa, MD, PhD, Masami Taniguchi, MD, PhD The Journal of Allergy and Clinical Immunology: In Practice Volume 6, Issue 1, Pages 116-125.e3 (January 2018) DOI: 10.1016/j.jaip.2017.04.035 Copyright © 2017 The Authors Terms and Conditions

Figure 1 Flow chart of patient enrollment. AERD, Aspirin-exacerbated respiratory disease; ATA, aspirin-tolerant asthma; ECRHS, European Community Respiratory Health Survey; HC, healthy control. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 116-125.e3DOI: (10.1016/j.jaip.2017.04.035) Copyright © 2017 The Authors Terms and Conditions

Figure 2 Schematic examples of smoking status classification. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 116-125.e3DOI: (10.1016/j.jaip.2017.04.035) Copyright © 2017 The Authors Terms and Conditions

Figure 3 Frequency of current smokers (A), past smokers (B), and all smokers (C) at the age of asthma onset. The age- and gender-adjusted frequency of each group was calculated with the HC group as the standard population. AERD, Aspirin-exacerbated respiratory disease; ATA, aspirin-tolerant asthma; HC, healthy control, n, total number of subjects; n′, number of subjects adjusted for age and gender distribution of healthy controls. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 116-125.e3DOI: (10.1016/j.jaip.2017.04.035) Copyright © 2017 The Authors Terms and Conditions

Figure 4 Adjusted odds ratios for the association between smoking cessation preceding asthma onset and the risk of AERD (smoking classification 2). The reference group was “never smoked.” AERD, Aspirin-exacerbated respiratory disease; ATA, aspirin-tolerant asthma; CI, confidence interval; HC, healthy control. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 116-125.e3DOI: (10.1016/j.jaip.2017.04.035) Copyright © 2017 The Authors Terms and Conditions

Figure 5 Detailed case histories of the timing of smoking cessation and the onset of respiratory symptoms. The reason for smoking cessation was the risk of future smoking-related health problems in cases 1, 3, and 4 and a nonsmoking policy in the workplace in case 2. AERD, Aspirin-exacerbated respiratory disease. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 116-125.e3DOI: (10.1016/j.jaip.2017.04.035) Copyright © 2017 The Authors Terms and Conditions

Figure E1 Odds ratios for the association between smoking cessation preceding asthma onset and the risk of AERD (smoking classification 2) after adjustment for asthma severity. The reference group was “never smoked.” AERD, Aspirin-exacerbated respiratory disease; ATA, aspirin-tolerant asthma; CI, confidence interval. The Journal of Allergy and Clinical Immunology: In Practice 2018 6, 116-125.e3DOI: (10.1016/j.jaip.2017.04.035) Copyright © 2017 The Authors Terms and Conditions