Neuromuscular blocking effects of cisatracurium and its antagonism with neostigmine in a canine model of autosomal-recessive centronuclear myopathy M.

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Neuromuscular blocking effects of cisatracurium and its antagonism with neostigmine in a canine model of autosomal-recessive centronuclear myopathy M. Martin-Flores, M.D. Paré, L. Campoy, R.D. Gleed British Journal of Anaesthesia Volume 115, Issue 6, Pages 927-931 (December 2015) DOI: 10.1093/bja/aev397 Copyright © 2015 The Author(s) Terms and Conditions

Fig 1 (A) Duration of neuromuscular block from cisatracurium (0.15 mg kg−1) administration to spontaneous return of TOF count of 2 in control and CNM dogs. (B) Time of return to TOF ratio ≥0.9 (normalized to baseline) after glycopyrrolate 0.01 mg kg−1 and neostigmine 0.04 mg kg−1 were administered at TOF count 2 in control and CNM dogs. *P=0.005; horizontal bar and whiskers are median and interquartile range, respectively. British Journal of Anaesthesia 2015 115, 927-931DOI: (10.1093/bja/aev397) Copyright © 2015 The Author(s) Terms and Conditions

Fig 2 Time course after cisatracurium (0.15 mg kg−1) of TOF ratio measured at the thoracic and pelvic limbs in three dogs with CNM. Discrepancies between simultaneous thoracic and pelvic limbs AMG can be seen in the middle and bottom traces. In the top trace TOF ratio in both limbs behaved similarly. In the middle trace the lowest TOF ratio (∼0.25) in the pelvic limb coincided with a TOF ratio of zero in the thoracic limb. In the bottom trace the TOF ration in the pelvic limb was 1.0 when the TOF ration in the thoracic limb was zero and no movement could be seen. British Journal of Anaesthesia 2015 115, 927-931DOI: (10.1093/bja/aev397) Copyright © 2015 The Author(s) Terms and Conditions