Multiplexing Visual Signals in the Suprachiasmatic Nuclei

Slides:



Advertisements
Similar presentations
A Sensorimotor Role for Traveling Waves in Primate Visual Cortex
Advertisements

Volume 93, Issue 2, Pages (January 2017)
Guangying K. Wu, Pingyang Li, Huizhong W. Tao, Li I. Zhang  Neuron 
Volume 81, Issue 4, Pages (February 2014)
Responses to Spatial Contrast in the Mouse Suprachiasmatic Nuclei
Soumya Chatterjee, Edward M. Callaway  Neuron 
Volume 36, Issue 5, Pages (December 2002)
Coding of the Reach Vector in Parietal Area 5d
The Generation of Direction Selectivity in the Auditory System
Two-Dimensional Substructure of MT Receptive Fields
Volume 14, Issue 11, Pages (March 2016)
Bassam V. Atallah, Massimo Scanziani  Neuron 
Selective Attention in an Insect Visual Neuron
Retinal Representation of the Elementary Visual Signal
Hiroki Asari, Markus Meister  Neuron 
Dynamic Processes Shape Spatiotemporal Properties of Retinal Waves
Hugh Pastoll, Lukas Solanka, Mark C.W. van Rossum, Matthew F. Nolan 
Volume 55, Issue 3, Pages (August 2007)
Circuit Mechanisms of a Retinal Ganglion Cell with Stimulus-Dependent Response Latency and Activation Beyond Its Dendrites  Adam Mani, Gregory W. Schwartz 
Responses of Collicular Fixation Neurons to Gaze Shift Perturbations in Head- Unrestrained Monkey Reveal Gaze Feedback Control  Woo Young Choi, Daniel.
Volume 93, Issue 2, Pages (January 2017)
Volume 36, Issue 5, Pages (December 2002)
Volume 75, Issue 1, Pages (July 2012)
Adaptation without Plasticity
Effects of Locomotion Extend throughout the Mouse Early Visual System
Nicholas J. Priebe, David Ferster  Neuron 
Thomas Akam, Dimitri M. Kullmann  Neuron 
Hippocampal “Time Cells”: Time versus Path Integration
Directional Selectivity Is Formed at Multiple Levels by Laterally Offset Inhibition in the Rabbit Retina  Shelley I. Fried, Thomas A. Mu¨nch, Frank S.
A Pixel-Encoder Retinal Ganglion Cell with Spatially Offset Excitatory and Inhibitory Receptive Fields  Keith P. Johnson, Lei Zhao, Daniel Kerschensteiner 
Volume 88, Issue 3, Pages (November 2015)
Experience-Dependent Asymmetric Shape of Hippocampal Receptive Fields
Volume 19, Issue 3, Pages (April 2017)
Eye Movements Modulate Visual Receptive Fields of V4 Neurons
The Information Content of Receptive Fields
Redundancy in the Population Code of the Retina
Natalja Gavrilov, Steffen R. Hage, Andreas Nieder  Cell Reports 
Origin and Function of Tuning Diversity in Macaque Visual Cortex
Prediction of Orientation Selectivity from Receptive Field Architecture in Simple Cells of Cat Visual Cortex  Ilan Lampl, Jeffrey S. Anderson, Deda C.
Ethan S. Bromberg-Martin, Masayuki Matsumoto, Okihide Hikosaka  Neuron 
Volume 84, Issue 2, Pages (October 2014)
Greg Schwartz, Sam Taylor, Clark Fisher, Rob Harris, Michael J. Berry 
Xiangying Meng, Joseph P.Y. Kao, Hey-Kyoung Lee, Patrick O. Kanold 
Michal Rivlin-Etzion, Wei Wei, Marla B. Feller  Neuron 
Local and Global Contrast Adaptation in Retinal Ganglion Cells
Timescales of Inference in Visual Adaptation
Stephen V. David, Benjamin Y. Hayden, James A. Mazer, Jack L. Gallant 
Adaptation without Plasticity
Volume 72, Issue 6, Pages (December 2011)
Receptive Fields of Disparity-Tuned Simple Cells in Macaque V1
Short-Term Memory for Figure-Ground Organization in the Visual Cortex
Gabe J. Murphy, Fred Rieke  Neuron 
Serotonergic Modulation of Sensory Representation in a Central Multisensory Circuit Is Pathway Specific  Zheng-Quan Tang, Laurence O. Trussell  Cell Reports 
Volume 30, Issue 2, Pages (May 2001)
Volume 24, Issue 8, Pages e6 (August 2018)
Dynamic Shape Synthesis in Posterior Inferotemporal Cortex
Colin J. Akerman, Darragh Smyth, Ian D. Thompson  Neuron 
Xiaowei Chen, Nathalie L. Rochefort, Bert Sakmann, Arthur Konnerth 
John B Reppas, W.Martin Usrey, R.Clay Reid  Neuron 
End-Stopping and the Aperture Problem
Multineuronal Firing Patterns in the Signal from Eye to Brain
The Postsaccadic Unreliability of Gain Fields Renders It Unlikely that the Motor System Can Use Them to Calculate Target Position in Space  Benjamin Y.
Volume 92, Issue 5, Pages (December 2016)
Jan Benda, André Longtin, Leonard Maler  Neuron 
Supratim Ray, John H.R. Maunsell  Neuron 
Volume 95, Issue 5, Pages e4 (August 2017)
Surround Integration Organizes a Spatial Map during Active Sensation
Valerio Mante, Vincent Bonin, Matteo Carandini  Neuron 
Maxwell H. Turner, Fred Rieke  Neuron 
David B. Kastner, Stephen A. Baccus  Neuron 
Presentation transcript:

Multiplexing Visual Signals in the Suprachiasmatic Nuclei Adam R. Stinchcombe, Joshua W. Mouland, Kwoon Y. Wong, Robert J. Lucas, Daniel B. Forger  Cell Reports  Volume 21, Issue 6, Pages 1418-1425 (November 2017) DOI: 10.1016/j.celrep.2017.10.045 Copyright © 2017 The Author(s) Terms and Conditions

Cell Reports 2017 21, 1418-1425DOI: (10.1016/j.celrep.2017.10.045) Copyright © 2017 The Author(s) Terms and Conditions

Figure 1 An Overview of the Mathematical Model Describing the GABA-Mediated Neuronal Network within the SCN (A) The visual filed is divided into squares representing the receptive fields of ipRGCs. A bar of light (yellow) falling on some squares results in some SCN neuron(s) experiencing a current via projections from the retinal ganglion cells in the retinohypothalamic tract (RHT) to the SCN (blue arrows). Within the SCN network, neurons can inhibit (flatheads) or excite (arrowheads) other SCN neurons depending on the reversal potential of GABA. The population consists of both neurons excited (green) and inhibited (red) by GABA. Approximately 20% of SCN neurons receive direct input (bright red and green), which is excitatory. Additional model details are described in the Experimental Procedures and Figures S1–S3. (B) Voltage traces (coloring from A; thick [thin] lines for spontaneously firing [quiescent] neurons) for a full-field light stimulus (yellow background) and an intact or removed (blue bar) GABA network. Inset: experimental voltage traces from Kononenko and Dudek (2004) with regular action potentials without GABA (left) and irregular action potentials with GABA (right) agreeing with the simulation. (C) A Raster plot for a small number of neurons (coloring from A) are shown for a stimulus of a vertical bar of light presented at different positions in the visual field. Bars are presented for 0.25 s with 0.25 s of background of low ambient light between presentations. The first three positions for the first 1.5 s are diagramed to the right. Neurons without direct input also have different firing rates, but increase or decrease their firing rates depending on how they are connected to the rest of the network. Cell Reports 2017 21, 1418-1425DOI: (10.1016/j.celrep.2017.10.045) Copyright © 2017 The Author(s) Terms and Conditions

Figure 2 Firing Rate Responses (A) Four voltage traces of select SCN neurons under a full-field light step (upper two are experimental, lower two are from the simulation). The left two traces show an increase in the firing rate while the right two show a decrease. (B) A scatterplot of firing rates during the on and off phases of the stimulus averaged over the 10 s before and after the step from the simulation (filled circles with coloring from Figure 1A) and experiments (black). (C) (i) Firing frequency distribution for various temporal inversion frequencies for a 14 × 14 checkerboard. Each column corresponds to a different inversion frequency and shows the firing rate histogram in color, as the fraction of the all SCN neurons. SCN neurons fire primarily around 4 Hz and resonate with that stimulus frequency. (ii) On a coarse spatial grid of 4 × 4 checkers and a 2-Hz inversion frequency, neurons with direct input (histogram in green) fire at 4 Hz while those without (histogram in black) fire between 2 Hz, the stimulus frequency, and 4 Hz. (D) For a 4 Hz inverting checkerboard stimulus and a range of irradiances, average population firing rate as the ratio of the firing rate for a given spatial contrast to that at the same irradiance and zero contrast. The GABA network is (i) intact and (ii) removed showing that the network reduces the SCN’s response to contrast. (E) The (horizontal bar) receptive fields (i and ii) for two SCN neurons (without direct input) and the timing of their spikes relative (iii and iv) to a 4-Hz inverting 14 × 14 checkerboard. Both full field neurons fire after each switch of the 4-Hz stimulus (every 125 ms). The delay is consistent with measured empirical data as the input is filtered through the GABA network. Cell Reports 2017 21, 1418-1425DOI: (10.1016/j.celrep.2017.10.045) Copyright © 2017 The Author(s) Terms and Conditions

Figure 3 Receptive Field Mapping Simulations (A) Changes in firing rates of selected neurons within the simulation as a function of bar position (spanning 200° of the visual field) exhibit various receptive fields. Only responses to vertically oriented bars are shown although both vertical and horizontal presentations are simulated. The receptive fields of two neurons from a poor fit simulation are shown. (B) The receptive fields from four neurons from the best-fit simulation. (C) Cumulative distribution of vertical bar receptive field sizes for data (red), the best-fit simulation (black), and a poor-fit simulation (blue). (D) The fraction of randomly generated networks that cannot be rejected are shown for two key network parameters: the fraction of the connections that are excitatory and the connection density. From this, we infer that the SCN GABA network is 20% excitatory with each neuron being directly connected to around 10 (1% of N = 1,024) other neurons. (E) The size of the largest connected component as a fraction of the size of the network as a function of the connection density for N = 10,000 (the size of the SCN). The first, second (median), and third quartiles of the distribution as shown, but the curves appear on top of one another. (F) A histogram with 40 bins of the visual field distance between connected neurons, separated into four types of connections: direct inhibitory (−1, bright red), effectively inhibitory through one intermediate neuron (−2, dark red), direct excitatory (+1, bright green), and effectively excitatory through one intermediate neuron (+2, dark green); total percentages of types are shown. The solid black curve is the distribution of pairwise distances that would result from uniformly random centers in a network of N = 1,024 neurons. Cell Reports 2017 21, 1418-1425DOI: (10.1016/j.celrep.2017.10.045) Copyright © 2017 The Author(s) Terms and Conditions

Figure 4 The GABA Network within the SCN Can Enhance Visual Tasks (A) Two Raster plots show that the GABA network encourages spiking in the ventral SCN (neurons with light input and are inhibited by GABA) for a 5 s ramp stimulus at circadian time (CT) 14.7. The spikes from 149, not sequentially numbered, neurons are shown. (B) Mean firing rate for all neurons (black) and for each network type (coloring from Figure 1A) for a slow ramp stimulus at CT 12 in four columns: GABA and RHT intact, GABA disabled, GABA permuted, and RHT permuted. The firing rates can increase or decrease with input in a direction opposite from that predicted by the sign of the GABA input. (C) Cumulative distribution of the in vivo experimentally measured ratio of firing rate for a full-field stimulus against that of background for cells with broad (blue) and confined (black) receptive field responses. (D) Receptive field centers (coloring from Figure 1A) of spiking neurons from ten not-rejected networks laid over the ipRGC receptive field grid. (E) Procedure to locate a bright spot: (1) the light input is perturbed with Gaussian noise with standard deviation σ, then (2a) directly passed directly or (2b) filtered by the SCN, and then (3) the controller moves the center of the visual field toward the largest signal. Movie S1 demonstrates the effect of tracking a bright spot with and without SCN filtering. (F) Gaze trajectory starting from 60° down and away from the bright spot on a 14 × 14 grid and σ = 0.3. (G) The mean displacement from the target once it is found as a function of σ. SCN filtering holds the gaze closer to the target. Cell Reports 2017 21, 1418-1425DOI: (10.1016/j.celrep.2017.10.045) Copyright © 2017 The Author(s) Terms and Conditions